Evidence map›Paper›PMID 30940215›Full record

Trial reportBMC research notes2019

Effect of food intake on 92 oncological biomarkers by the Proseek Oncology II panel.

Magnus Dencker, Ola Björgell, Joanna Hlebowicz

Registry-linked trialOpen access · goldAbstract readClinical Trial
In one paragraph

Trial report in BMC research notes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01027507 (Relationship Between Postprandial Alterations in Hemodynamics, Blood Pressure, Blood Glucose, Insulin Concentrations, Gastric Emptying, and Satiety), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01027507 completednot on this map

Relationship Between Postprandial Alterations in Hemodynamics, Blood Pressure, Blood Glucose, Insulin Concentrations, Gastric Emptying, and Satiety

TypeobservationalSponsorSkane University HospitalRan2009 to 2009Enrolled23ConditionsHeart Disease
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Magnus DenckerDepartment of Medical Imaging and Physiology, Skåne University Hospital, Lund University, 205 02, Malmö, Sweden. magnus.dencker@skane.se.ORCID http://orcid.org/0000-0001-9991-3712
Ola BjörgellDepartment of Medical Imaging and Physiology, Skåne University Hospital, Lund University, 205 02, Malmö, Sweden.
Joanna HlebowiczDepartment of Clinical Sciences, Division of Medicine, Skåne University Hospital, Lund University, Malmö, Sweden.
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluates the effect of food intake on 92 oncological biomarkers to evaluate whether the timing of blood sampling could be relevant. Twenty-two healthy subjects were investigated. A total of 92 biomarkers were measured before a standardised meal as well as 30 and 120 min afterwards with the Proseek Multiplex Oncology II kit.

resultsThe levels of 6 biomarkers decreased significantly (P < 0.001) 30 min after food intake, and 4 biomarkers remained decreased (P < 0.001) 120 min after food intake. One biomarker was significantly increased (P < 0.001) at both 30 and 120 min after food intake. Some changes were less than 10%. Those biomarkers that showed a difference of more than 10% include: Granzyme H (13%), Methionine aminopeptidase 2 (14%), Secretory carrier-associated membrane protein 3 (39%), FAS-associated death domain protein (41%), and Pancreatic prohormone (79%). This study shows that food intake has a very modest effect on 92 different oncological biomarkers. Trial registration National Library of Medicine trial registration number NCT01027507 (retrospectively registered on December 8, 2009).

Indexed as

EatingAdultBiomarkers, TumorClinical Laboratory TechniquesFemaleHumansMaleProteomicsYoung AdultBiomarkers, TumorOlinkProseek Oncology II

Identifiers

PMID30940215
PMCPMC6446403
OpenAlexW2942879388

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.