Observational studyJournal of cardiothoracic surgery2019
Impact of bleeding complications on length of stay and critical care utilization in cardiac surgery patients in England.
Observational study in Journal of cardiothoracic surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Machine learning and artificial intelligence in cardiac transplantation: A systematic review.Artificial organs · 2022Pooled it
- Trial
- Cost-Effectiveness of Cryopreserved vs Liquid-Stored Platelets for Managing Surgical Bleeding.JAMA network open · 2025Trial
- A Study of Safety and Effectiveness of Evicel Fibrin Sealant as an Adjunctive Hemostat in Pediatric Surgery.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2024Trial
- Early anti-coagulation therapy in new-onset atrial fibrillation after coronary artery bypass grafting: a randomized trial pilot study.BMC cardiovascular disorders · 2024Trial
- Safety and efficacy of a kaolin-impregnated hemostatic gauze in cardiac surgery: A randomized trial.JTCVS open · 2023Trial
- Safety and Hemostatic Effectiveness of SURGICEL® Powder in Mild and Moderate Intraoperative Bleeding.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisTrial
- Article
- Efficacy of postoperative tranexamic acid administration in patients undergoing proximal femoral tumor endoprosthesis reconstruction.Perioperative medicine (London, England) · 2026Article
- Health-related quality of life pre-war and during-war in cardiac patients: evidence from a multicenter prospective study - West Bank.Health and quality of life outcomes · 2026Article
- Machine learning in critical care: Improving prediction of mortality and intensive care unit stay after cardiac surgery.JTCVS open · 2026Article
- Structural and Non-Structural Deterioration After Biological Aortic Valve Replacement: Long-Term Outcomes of 918 High-Risk Patients.Journal of cardiovascular development and disease · 2026Article
- Long-Term Safety and Performance of a National Pericardium Organic Valvular Bioprosthesis in the Brazilian Public Health System: Retrospective Analysis Up To 26 Years of Follow-up.Brazilian journal of cardiovascular surgery · 2025Article
- An In-depth overview of artificial intelligence (AI) tool utilization across diverse phases of organ transplantation.Journal of translational medicine · 2025Review
- Intraoperative Hemostatic Agents in Thoracic Aortic Surgery-A Scoping Review.Journal of clinical medicine · 2025Review
- Retrospective Database Analysis of the Clinical and Economic Outcomes Associated with Disruptive Surgical Bleeding.ClinicoEconomics and outcomes research : CEOR · 2025Article
- Angiotensin-II for vasoplegia following cardiac surgery.Perfusion · 2024Article
- POBS-Card, a new score of severe bleeding after cardiac surgery: Construction and external validation.JTCVS open · 2024Article
- Article
- Anemia after cardiac surgery: what is its link to outcomes?Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBleeding is a significant complication in cardiac surgery and is associated with substantial morbidity and mortality. This study evaluated the impact of bleeding on length of stay (LOS) and critical care utilization in a nationwide sample of cardiac surgery patients treated at English hospitals.
methodsRetrospective, observational cohort study using linked English Hospital Episode Statistics (HES) and Clinical Practice Research Datalink (CPRD) records for a nationwide sample of patients aged ≥18 years who underwent coronary artery bypass graft (CABG), valve repair/replacement, or aortic operations from January 2010 through February 2016. The primary independent variables were in-hospital bleeding complications and reoperation for bleeding before discharge. Generalized linear models were used to quantify the adjusted mean incremental difference [MID] in post-procedure LOS and critical care days associated with bleeding complications, independent of measured baseline characteristics.
resultsThe study included 7774 cardiac surgery patients (3963 CABG; 2363 valve replacement/repair; 160 aortic procedures; 1288 multiple procedures, primarily CABG+valve). Mean LOS was 10.7d, including a mean of 4.2d in critical care. Incidences of in-hospital bleeding complications and reoperation for bleeding were 6.7 and 0.3%, respectively. Patients with bleeding had longer LOS (MID: 3.1d; p < 0.0001) and spent more days in critical care (MID: 2.4d; p < 0.0001). Reoperation for bleeding was associated with larger increases in LOS (MID = 4.0d; p = 0.002) and days in critical care (MID = 3.2d; p = 0.001).
conclusionsAmong English cardiac surgery patients, in-hospital bleeding complications were associated with substantial increases in healthcare utilization. Increased use of evidence-based strategies to prevent and manage bleeding may reduce the clinical and economic burden associated with bleeding complications in cardiac surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.