ArticleBMC cancer2019
Multimodal multiphoton imaging for label-free monitoring of early gastric cancer.
Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Label-Free Monitoring of Endometrial Cancer Progression Using Multiphoton Microscopy.Annals of biomedical engineering · 2024Article
- Label-free multimodal imaging with simultaneous two-photon and three-photon microscopy and kernel-based nonlinear scaling denoising.Biomedical optics express · 2024Article
- Toward next-generation endoscopes integrating biomimetic video systems, nonlinear optical microscopy, and deep learning.Biophysics reviews · 2023Review
- Rapid and label-free detection of gastrointestinal stromal tumor via a combination of two-photon microscopy and imaging analysis.BMC cancer · 2023Article
- Genomic analysis of matrix metalloproteinases affecting the prognosis and immunogenic profile of gastric cancer.Frontiers in genetics · 2023Article
- Multiphoton excitation imaging via an actively mode-locked tunable fiber-cavity SOA laser around 800 nm.Biomedical optics express · 2022Article
- Review
- Optical biopsy of laryngeal lesions using femtosecond multiphoton microscopy.Biomedical optics express · 2021Article
- Navigating the Collagen Jungle: The Biomedical Potential of Fiber Organization in Cancer.Bioengineering (Basel, Switzerland) · 2021Review
- Analysis on the Characterization of Multiphoton Microscopy Images for Malignant Neoplastic Colon Lesion Detection under Deep Learning Methods.Journal of pathology informatics · 2021Article
- Label-free characterization of collagen fibers in cancerous esophagus tissues using ratiometric nonlinear optical microscopy.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Label-free multiphoton imaging to assess neoadjuvant therapy responses in breast carcinoma.International journal of biological sciences · 2020Article
- Label-free identification of early gastrointestinal neuroendocrine tumors via biomedical multiphoton microscopy and automatic image analysis.IEEE access : practical innovations, open solutions · 2020Article
- Application of Multiphoton Microscopic Imaging in Study of Gastric Cancer.Technology in cancer research & treatmentReview
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly gastric cancer is associated with a much better prognosis than advanced disease, and strategies to improve prognosis is strictly dependent on earlier detection and accurate diagnosis. Therefore, a label-free, non-invasive imaging technique that allows the precise identification of morphologic changes in early gastric cancer would be of considerable clinical interest.
methodsIn this study, multiphoton microscopy (MPM) using two-photon excited fluorescence combined with second-harmonic generation was used for the identification of early gastric cancer.
resultsThis microscope was able to directly reveal improved cellular detail and stromal changes during the development of early gastric cancer. Furthermore, two features were quantified from MPM images to assess the cell change in size and stromal collagen change as gastric lesion developed from normal to early cancer.
conclusionsThese results clearly show that multiphoton microscopy can be used to examine early gastric cancer at the cellular level without the need for exogenous contrast agents. This study would be helpful for early diagnosis and treatment of gastric cancer, and may provide the groundwork for further exploration into the application of multiphoton microscopy in clinical practice.
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