Evidence map›Paper›PMID 30939798›Full record

ArticleInternational journal of molecular sciences2019

Fluvastatin Sodium Ameliorates Obesity through Brown Fat Activation.

Na Yin, Hanlin Zhang, Rongcai Ye, Meng Dong, Jun Lin, Huiqiao Zhou, Yuanyuan Huang, Li Chen, Xiaoxiao Jiang, Kentaro Nagaoka and 2 more

Open access · goldFull text read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. AAV-mediated BMP7 gene therapy counteracts insulin resistance and obesity.Molecular therapy. Methods & clinical development · 2022
    Article
  5. Article
  6. Chronic hindbrain administration of oxytocin elicits weight loss in male diet-induced obese mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Na YinKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. yinna@ioz.ac.cn.
Hanlin ZhangKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. zhanghanlin@ioz.ac.cn.
Rongcai YeKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. yerongcai@126.com.
Meng DongKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. dongmeng90@foxmail.com.
Jun LinKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. cleverlinjun@126.com.
Huiqiao ZhouKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. jessicachou36@126.com.
Yuanyuan HuangKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. lvhaizi@sina.com.
Li ChenKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. 18811322312@163.com.
Xiaoxiao JiangKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. xiaoxiao0826@126.com.
Kentaro NagaokaLaboratory of Veterinary Physiology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan. nagaokak@cc.tuat.ac.jp.
Chuanhai ZhangKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. zhangchuanhai.68@163.com.ORCID 0000-0001-7644-2436
Wanzhu JinKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. jinw@ioz.ac.cn.
Chinese Academy of Sciences · CNTokyo University of Agriculture and Technology · JP

Funding

National Natural Science Foundation of China 81700684, 81770834, 81370951National Natural Science Foundation of China Y21JA71234the National Key Research and Development Program of China 2017YFC1001001the Strategic Priority Research Program (XDB13030000) from the Chinese Academy of Sciences XDB13030000
6 · The paper itself

Abstract

Brown adipose tissue (BAT), an organ that burns energy through uncoupling thermogenesis, is a promising therapeutic target for obesity. However, there are still no safe anti-obesity drugs that target BAT in the market. In the current study, we performed large scale screening of 636 compounds which were approved by Food and Drug Administration (FDA) to find drugs that could significantly increase uncoupling protein 1 (

Indexed as

Adipose Tissue, BrownAnimalsAnti-Obesity AgentsCells, CulturedEnergy MetabolismFluvastatinHumansMaleMiceMice, Inbred C57BLObesityUncoupling Protein 1Anti-Obesity AgentsFluvastatinUcp1 protein, mouseUncoupling Protein 1activatorbrown adipose tissuefluvastatin sodiumobesity

Identifiers

PMID30939798
PMCPMC6479292
OpenAlexW2929306280

What OpenQuestion holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.