ArticleJournal of functional biomaterials2019
3D Printing Custom Bioactive and Absorbable Surgical Screws, Pins, and Bone Plates for Localized Drug Delivery.
Article in Journal of functional biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Antibacterial cellulose composite: using SET-LRP for cellulose surface modification with quaternized poly-dimethylammoniumethylacrylate.RSC advances · 2026Article
- HME-FDM 3D-Printed Implantable Drug Delivery Systems-From Design to Characterization.Pharmaceutics · 2026Review
- Impact of 3D technology on perioperative outcomes of articular and periarticular fractures: A systematic review and meta-analysis of RCT studies.Journal of orthopaedics · 2026Review
- Evaluation of Selected Properties of Ti Coatings Deposited on MED610 for Medical Applications.Materials (Basel, Switzerland) · 2025Article
- Development and Characterization of Biodegradable Polymer Filaments for Additive Manufacturing.Polymers · 2025Article
- Advances in 3D-Printed Drug Delivery and Screening Platforms for Bone Disease Therapy.Pharmaceutics · 2025Review
- 3d-Printed One-Third Tubular Plates in an Ankle Fracture Model: A Biomechanical Study.The Iowa orthopaedic journal · 2025Article
- Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction.Biomimetics (Basel, Switzerland) · 2024Review
- Impact of mechanical engineering innovations in biomedical advancements.In vitro models · 2024Review
- Vancomycin-Loaded 3D-Printed Polylactic Acid-Hydroxyapatite Scaffolds for Bone Tissue Engineering.Polymers · 2023Article
- Article
- Analysis of the Mechanical Behavior of Porcine Graft Fixation in a Polyurethane Block Using a 3D-printed PLA Interference Screw.Revista brasileira de ortopedia · 2023Article
- Investigation of the In Vitro and In Vivo Biocompatibility of a Three-Dimensional Printed Thermoplastic Polyurethane/Polylactic Acid Blend for the Development of Tracheal Scaffolds.Bioengineering (Basel, Switzerland) · 2023Article
- The Evolution of the 3D-Printed Drug Delivery Systems: A Review.Pharmaceutics · 2022Review
- 3D Printing and Virtual Surgical Planning in Oral and Maxillofacial Surgery.Journal of clinical medicine · 2022Review
- Article
- 3D-Printing of Drug-Eluting Implants: An Overview of the Current Developments Described in the Literature.Molecules (Basel, Switzerland) · 2021Review
- Recent Advances in 3D Printing for Parenteral Applications.The AAPS journal · 2021Review
- Three-Dimensional Printed Antimicrobial Objects of Polylactic Acid (PLA)-Silver Nanoparticle Nanocomposite Filaments Produced by an In-Situ Reduction Reactive Melt Mixing Process.Biomimetics (Basel, Switzerland) · 2020Article
- Additive manufacturing of biodegradable porous orthopaedic screw.Bioactive materials · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Additive manufacturing has great potential for personalized medicine in osseous fixation surgery, including maxillofacial and orthopedic applications. The purpose of this study was to demonstrate 3D printing methods for the fabrication of patient-specific fixation implants that allow for localized drug delivery. 3D printing was used to fabricate gentamicin (GS) and methotrexate (MTX)-loaded fixation devices, including screws, pins, and bone plates. Scaffolds with different infill ratios of polylactic acid (PLA), both without drugs and impregnated with GS and MTX, were printed into cylindrical and rectangular-shaped constructs for compressive and flexural strength mechanical testing, respectively. Bland PLA constructs showed significantly higher flexural strength when printed in a Y axis at 100% infill compared to other axes and infill ratios; however, there was no significant difference in flexural strength between other axes and infill ratios. GS and MTX-impregnated constructs had significantly lower flexural and compressive strength as compared to the bland PLA constructs. GS-impregnated implants demonstrated bacterial inhibition in plate cultures. Similarly, MTX-impregnated implants demonstrated a cytotoxic effect in osteosarcoma assays. This proof of concept work shows the potential of developing 3D printed screws and plating materials with the requisite mechanical properties and orientations. Drug-impregnated implants were technically successful and had an anti-bacterial and chemotherapeutic effect, but drug addition significantly decreased the flexural and compressive strengths of the custom implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.