Evidence map›Paper›PMID 30939596›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019

Group II metabotropic glutamate receptor blockade promotes stress resilience in mice.

Jaclyn N Highland, Panos Zanos, Polymnia Georgiou, Todd D Gould

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. PeripheralNeuropsychiatric disease and treatment · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
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  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Advances in translating mGluPharmacology, biochemistry, and behavior · 2022
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jaclyn N HighlandDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-9600-2830
Panos ZanosDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Polymnia GeorgiouDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Todd D GouldDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. gouldlab@me.com.
University of Maryland, Baltimore · US

Funding

Therapeutic Efficacy of Ketamine Metabolites for Depression TreatmentR01MH107615 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI GOULD, TODD D · 2016 to 2025
$7.2M
TRAINING PROGRAM IN INTEGRATIVE MEMBRANE BIOLOGYT32GM008181 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI RIZZO, MEGAN A, TRUDEAU, MATTHEW C · 1987 to 2022
$4.9M
NIGMS NIH HHS T32 GM008181NIMH NIH HHS R01 MH107615
6 · The paper itself

Abstract

Stress is a leading risk factor for the onset and recurrence of major depression. Enhancing stress resilience may be a therapeutic strategy to prevent the development of depression in at-risk populations or its recurrence in depressed patients. Group II metabotropic glutamate receptor (mGlu

Indexed as

Resilience, PsychologicalAmino AcidsAnhedoniaAnimalsBehavior, AnimalCorticosteroneElectroshockEscape ReactionExcitatory Amino Acid AntagonistsMiceMice, KnockoutReceptors, Metabotropic GlutamateStress, PsychologicalXanthenesAmino AcidsCorticosteroneExcitatory Amino Acid AntagonistsLY 341495metabotropic glutamate receptor 2metabotropic glutamate receptor 3Receptors, Metabotropic GlutamateXanthenes

Identifiers

PMID30939596
PMCPMC6785136
OpenAlexW2934055545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.