Evidence map›Paper›PMID 30939488›Full record

Observational studyClinical and translational gastroenterology2019

Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt.

Michael Praktiknjo, Caroline Clees, Alessandra Pigliacelli, Stefan Fischer, Christian Jansen, Jennifer Lehmann, Alessandra Pohlmann, Barbara Lattanzi, Viktoria Katharina Krabbe, Christian P Strassburg and 4 more

2 registry-linked trialsOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical and translational gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 60 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 6 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03584204 recruitingnot on this map

Role of Skeletal Muscle Parameters in Imaging Analysis in the Prediction of Outcome in Patients With Liver Cirrhosis

TypeobservationalSponsorUniversity Hospital, BonnRan2018 to 2026Enrolled400ConditionsLiver CirrhosisArmsimaging
NCT06857682 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Haematological Indices as a Prognostic Predictor Among Patients With Acute on Top of Chronic Liver Cell Failure

TypeobservationalSponsorAssiut UniversityRan2024 to 2027Enrolled170ConditionsAcute on Top of Chronic Liver Cell Failure
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 6 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Pooled it
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  7. Trial
  8. [Research advances in immune and metabolic dysregulation in the diagnosis and treatment of acute-on-chronic liver failure].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  9. Article
  10. Sarcopenia Predicts Mortality and Hepatic Encephalopathy After TIPS in Older Adults With Cirrhosis and Improves Prognostic Scores.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  11. Review
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  16. Article
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  19. The clinical relevance of acute-on-chronic liver failure in medical procedures: Endoscopy, interventions and surgery.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Michael PraktiknjoDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
Caroline CleesDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
Alessandra PigliacelliDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
Stefan FischerDepartment of Radiology, University of Bonn, Bonn, Germany.
Christian JansenDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
Jennifer LehmannDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
Alessandra PohlmannDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
Barbara LattanziDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
Viktoria Katharina KrabbeDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
Christian P StrassburgDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
Vicente ArroyoEuropean Foundation for the Study of Chronic Liver Failure-EF CLIF, Barcelona, Spain.
Manuela MerliDepartment of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
Carsten MeyerDepartment of Radiology, University of Bonn, Bonn, Germany.
Jonel TrebickaDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
University of Bonn · DESapienza University of Rome · ITEuropean Foundation for the Study of Chronic Liver Failure · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMuscle mass has been shown to be a prognostic marker in patients with liver cirrhosis. Transversal psoas muscle thickness normalized by height (TPMT/height) obtained by routine computed tomography is a simple surrogate parameter for sarcopenia. TPMT/height, however, is not sex specific, which might play a role in risk stratification. Its association with acute-on-chronic liver failure (ACLF) has not been established yet. ACLF is associated with systemic inflammatory dysregulation. This study aimed at evaluating the role of sarcopenia in ACLF development of patients with decompensated cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS) using sex-specific TPMT/height.

methodsOne hundred eighty-six patients from the prospective Non-invasive Evaluation Program for TIPS and Follow Up Network cohort (observational, real-world TIPS cohort with structured follow-up) were analyzed. TPMT/height was measured from routine computed tomography. The sex-specific cutoff was determined to classify patients as sarcopenic and nonsarcopenic for 1-year mortality after TIPS. Clinical outcome was compared. Primary end points were ACLF and 1-year mortality after TIPS. Secondary end points were development of decompensations (hepatic encephalopathy and ascites) after TIPS.

resultsThe sex-specific cutoff increases the diagnostic accuracy with regard to primary and secondary end points compared with the unisex cutoff. Sex-specific sarcopenia classification is an independent predictor of 1-year mortality and ACLF development in patients with cirrhosis receiving TIPS. Patients in the sarcopenia group showed significantly higher rates of mortality, ascites, overt hepatic encephalopathy, and ACLF after TIPS compared with the nonsarcopenia group. The Chronic Liver Failure Consortium Acute Decompensation score as a marker of systemic inflammation was significantly higher in sarcopenic patients.

conclusionsThis study demonstrates for the first time that sarcopenia is related to ACLF development and systemic inflammation. The prognostic value of TPMT/height can be improved by using sex-specific cutoffs. ClinicalTrials.gov identifier: NCT03584204.

Indexed as

Acute-On-Chronic Liver FailureAdolescentAdultAgedAged, 80 and overBody HeightFemaleFollow-Up StudiesHumansLiver CirrhosisMaleMiddle AgedPortasystemic Shunt, Transjugular IntrahepaticPrognosisProspective StudiesPsoas Muscles

Identifiers

PMID30939488
PMCPMC6602782
OpenAlexW2937236065

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.