Evidence map›Paper›PMID 30938288›Full record

ArticleeLife2019

A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway in

Nick D Pokorzynski, Amanda J Brinkworth, Rey Carabeo

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Coordinated topoisomerase function shapes the fluoroquinolone response ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Anti-International journal of molecular sciences · 2026
    Review
  5. Article
  6. Cervicovaginal microbial features predictInfection and immunity · 2025
    Article
  7. Article
  8. Influence of cervicovaginal microbiota onMicrobial cell (Graz, Austria) · 2025
    Review
  9. Review
  10. Article
  11. Recognition ofInfection and immunity · 2024
    Article
  12. Metabolism and physiology of pathogenic bacterial obligate intracellular parasites.Frontiers in cellular and infection microbiology · 2024
    Review
  13. Review
  14. Review
  15. Molecular pathogenesis ofFrontiers in cellular and infection microbiology · 2023
    Review
  16. Genome organization and genomics inFrontiers in cellular and infection microbiology · 2023
    Review
  17. Article
  18. The role of tryptophan inFrontiers in cellular and infection microbiology · 2022
    Review
  19. Article
  20. Genetic susceptibility loci forFrontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nick D PokorzynskiCenter for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, United States.ORCID 0000-0003-2438-2368
Amanda J BrinkworthCenter for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, United States.ORCID 0000-0003-3340-8494
Rey CarabeoCenter for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, United States.ORCID 0000-0002-5708-5493
National Institutes of Health · US

Funding

TRAINING IN BIOTECHNOLOGY: EMPHASIS ON PROTEIN CHEMISTRYT32GM008336 · NIGMS · WASHINGTON STATE UNIVERSITY · PI CALL, DOUGLAS R. · 1989 to 2023
$8.9M
Infectious Diseases and Microbial Immunology Training ProgramT32AI007025 · NIAID · WASHINGTON STATE UNIVERSITY · PI Thomas H KAWULA, M KARIUKI NJENGA · 1985 to 2026
$7.4M
CHLAMYDIAL INVASION OF NON-PHAGOCYTIC CELLSR01AI065545 · NIAID · WASHINGTON STATE UNIVERSITY · PI CARABEO, REY A · 2005 to 2021
$3.3M
Regulatory Role of Tandem Tryptophan Codons in Chlamydial PersistenceR01AI132406 · NIAID · WASHINGTON STATE UNIVERSITY · PI CARABEO, REY A, OUELLETTE, SCOT P · 2019 to 2023
$2.9M
The molecular basis for integration of the Chlamydial responses to iron and tryptophan limitationF31AI136295 · NIAID · WASHINGTON STATE UNIVERSITY · PI POKORZYNSKI, NICHOLAS DAVID · 2018 to 2020
$94k
NIAID NIH HHS F31 AI136295NIAID NIH HHS R01 AI065545NIAID NIH HHS R01 AI132406NIAID NIH HHS T32 AI007025NIGMS NIH HHS T32 GM008336NIH HHS AI065545NIH HHS AI132406NIH HHS F31AI136295NIH HHS T32AI007025NIH HHS T32GM008336
6 · The paper itself

Abstract

During infection, pathogens are starved of essential nutrients such as iron and tryptophan by host immune effectors. Without conserved global stress response regulators, how the obligate intracellular bacterium

Indexed as

Gene Expression Regulation, BacterialOperonBacterial ProteinsChlamydia trachomatisEscherichia coli ProteinsIronMetabolic Networks and PathwaysPromoter Regions, GeneticRepressor ProteinsTranscription, GeneticTryptophanBacterial ProteinsEscherichia coli ProteinsIronRepressor ProteinsTRPR protein, E coliTryptophanChlamydia trachomatischromosomesgene expressioninfectious diseaseiron-dependent regulationmicrobiologyrepressionstress responsetranscriptiontryptophan biosynthesis

Identifiers

PMID30938288
PMCPMC6504234
OpenAlexW2931695210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.