Evidence map›Paper›PMID 30938271›Full record

ArticleRegenerative medicine2019

Stem cell culture conditions and stability: a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform.

Glyn N Stacey, Peter W Andrews, Ivana Barbaric, Charlotta Boiers, Amit Chandra, Giulio Cossu, Lynn Csontos, Thomas Jr Frith, Jason A Halliwell, Zoe Hewitt and 10 more

Abstract read
In one paragraph

Article in Regenerative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Glyn N StaceyInternational Stem Cell Banking Initiative, 2 High Street, Barley, Hertfordshire SG8 8HZ, UK.
Peter W AndrewsCentre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield, S10 2TN, UK.
Ivana BarbaricCentre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield, S10 2TN, UK.
Charlotta BoiersDepartment of Cancer Biology, University College London, London, WC1E 6DD, UK.
Amit ChandraYposkesi, 91100 Corbiel-Essonnes, France.
Giulio CossuDivision of Cell Matrix Biology & Regenerative Medicine, University of Manchester, M13 9PL, UK.
Lynn CsontosSTEMCELL Technologies, Waterbeach, CB25 9TL, UK.
Thomas Jr FrithCentre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield, S10 2TN, UK.
Jason A HalliwellCentre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield, S10 2TN, UK.
Zoe HewittCentre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield, S10 2TN, UK.
Mark McCallCentre for Biological Engineering, Loughborough University, Loughborough, LE11 3TU, UK.
Harry D MooreCentre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield, S10 2TN, UK.
Malin ParmarDevelopmental & Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund, S221 84, Sweden.
M Beatrice PanicoMedicines & Healthcare products Regulatory Agency, London, E14 4PU, UK.
Venkat PisupatiJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Valentin P ShichkinResearch Centre of Immunology & Biomedical Technologies, Open International University of Human Development Ukraine, Kyiv 03115, Ukraine.
Alison R StaceyDivision of Cell Matrix Biology & Regenerative Medicine, University of Manchester, M13 9PL, UK.
Francesco S TedescoDepartment of Cell & Developmental Biology & Great Ormond Street Institute of Child Health, University College London, WC1E 6DE, UK.
Oliver ThompsonCentre for Stem Cell Biology, Department of Biomedical Science, The University of Sheffield, Sheffield, S10 2TN, UK.
Ravenska WageySTEMCELL Technologies, Vancouver, BC, V6A 1B6, Canada.

Funding

European Research Council 759108Medical Research Council MR/L012537/1Medical Research Council MR/R015724/1Medical Research Council MR/S015116/1
6 · The paper itself

Abstract

Human stem cells have the potential to transform medicine. However, hurdles remain to ensure that manufacturing processes produce safe and effective products. A thorough understanding of the biological processes occurring during manufacture is fundamental to assuring these qualities and thus, their acceptability to regulators and clinicians. Leaders in both human pluripotent and somatic stem cells, were brought together with experts in clinical translation, biomanufacturing and regulation, to discuss key issues in assuring appropriate manufacturing conditions for delivery of effective and safe products from these cell types. This report summarizes the key issues discussed and records consensus reached by delegates and emphasizes the need for accurate language and nomenclature in the scientific discourse around stem cells.

Indexed as

Cell DifferentiationRegenerative MedicineAdult Stem CellsCell- and Tissue-Based TherapyCell Culture TechniquesCongresses as TopicHumansPluripotent Stem Cellscell-based medicinescell therapycharacterization regulationclinical trialmanufacturingmesenchymal cellspluripotent stem cellsregenerative medicine

Identifiers

PMID30938271
PMCPMC7611410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.