Evidence map›Paper›PMID 30938226›Full record

ArticleThyroid : official journal of the American Thyroid Association2019

Reduced Sensitivity to Thyroid Hormone as a Transgenerational Epigenetic Marker Transmitted Along the Human Male Line.

João Anselmo, Neal H Scherberg, Alexandra M Dumitrescu, Samuel Refetoff

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

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  5. Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders.Journal of autism and developmental disorders · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

João Anselmo1 Department of Endocrinology and Nutrition, Hospital Divino Espírito Santo, Ponta Delgada, Azores, Portugal.
Neal H Scherberg2 Department of Medicine, The University of Chicago, Chicago, Illinois.
Alexandra M Dumitrescu2 Department of Medicine, The University of Chicago, Chicago, Illinois.
Samuel Refetoff2 Department of Medicine, The University of Chicago, Chicago, Illinois.
University of Chicago · USHospital do Divino Espírito Santo · PTUniversity of Illinois Chicago · US

Funding

THYROID PHYSIOLOGY STUDIES OF INHERITED DISORDERSR01DK015070 · NIDDK · UNIVERSITY OF CHICAGO · PI ANTONIO C BIANCO, Alexandra Mihaela Dumitrescu · 1986 to 2026
$8.1M
THYROID PHYSIOLOGY STUDIES OF INHERITED DISORDERSR37DK015070 · NIDDK · UNIVERSITY OF CHICAGO · PI REFETOFF, SAMUEL · 1989 to 2015
$5.6M
Mouse Sbp2 deficiency models the multi-system syndrome of human SBP2 defectsR01DK110322 · NIDDK · UNIVERSITY OF CHICAGO · PI DUMITRESCU, ALEXANDRA MIHAELA · 2016 to 2020
$1.8M
NIDDK NIH HHS R01 DK015070NIDDK NIH HHS R01 DK110322NIDDK NIH HHS R37 DK015070
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Epigenesis, GeneticMutation, MissenseAdolescentAdultFemaleGenotypeHumansMalePhenotypePregnancyPrenatal Exposure Delayed EffectsThyroid Hormone Receptors betaThyroid HormonesYoung AdultThyroid Hormone Receptors betaThyroid Hormonesepigenetichumaninheritancereduced sensitivity to thyroid hormonetransgenerational

Identifiers

PMID30938226
PMCPMC6588120
OpenAlexW2925857449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.