Evidence map›Paper›PMID 30938037›Full record

ArticleTropical medicine & international health : TM & IH2019

Programmatic outcomes and impact of rapid public sector antiretroviral therapy expansion in adults prior to introduction of the WHO treat-all approach in rural Eswatini.

Bernhard Kerschberger, Michael Schomaker, Iza Ciglenecki, Lorraine Pasipamire, Edwin Mabhena, Alex Telnov, Barbara Rusch, Nomthandazo Lukhele, Roger Teck, Andrew Boulle

Abstract readMulticenter Study
In one paragraph

Article in Tropical medicine & international health : TM & IH, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bernhard KerschbergerMédecins Sans Frontières (Operational Centre Geneva), Mbabane, Eswatini.
Michael SchomakerCentre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Iza CigleneckiMédecins Sans Frontières (Operational Centre Geneva), Geneva, Switzerland.
Lorraine PasipamireMédecins Sans Frontières (Operational Centre Geneva), Mbabane, Eswatini.
Edwin MabhenaMédecins Sans Frontières (Operational Centre Geneva), Mbabane, Eswatini.
Alex TelnovMédecins Sans Frontières (Operational Centre Geneva), Geneva, Switzerland.
Barbara RuschMédecins Sans Frontières (Operational Centre Geneva), Geneva, Switzerland.
Nomthandazo LukheleSwaziland National AIDS Programme, Ministry of Health, Mbabane, Eswatini.
Roger TeckMédecins Sans Frontières, London, UK.
Andrew BoulleCentre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess long-term antiretroviral therapy (ART) outcomes during rapid HIV programme expansion in the public sector of Eswatini (formerly Swaziland).

methodsThis is a retrospectively established cohort of HIV-positive adults (≥16 years) who started first-line ART in 25 health facilities in Shiselweni (Eswatini) between 01/2006 and 12/2014. Temporal trends in ART attrition, treatment expansion and ART coverage were described over 9 years. We used flexible parametric survival models to assess the relationship between time to ART attrition and covariates.

resultsOf 24 772 ART initiations, 6% (n = 1488) occurred in 2006, vs. 13% (n = 3192) in 2014. Between these years, median CD4 cell count at ART initiation increased (113-265 cells/mm

conclusionsProgrammatic outcomes improved during large expansion of the treatment cohort and increased ART coverage. Changes in ART programming may have contributed to better outcomes.

Indexed as

Drug MonitoringAdultAnti-HIV AgentsCD4 Lymphocyte CountEligibility DeterminationEswatiniFemaleHIV InfectionsHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisPregnancyProgram EvaluationProportional Hazards ModelsAnti-HIV AgentsART expansionattritionEswatiniexpansion de l’ARTSwazilandtemporal trendstendances temporelles

Identifiers

PMID30938037
PMCPMC6849841

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.