Evidence map›Paper›PMID 30937914›Full record

ReviewVox sanguinis2019

Canadian expert consensus: management of hypersensitivity reactions to intravenous iron in adults.

Wendy Lim, Waqqas Afif, Sandra Knowles, Gloria Lim, Yulia Lin, Charmaine Mothersill, Irina Nistor, Faisal Rehman, Christine Song, Ted Xenodemetropoulos

Open access · hybridAbstract readReviewConsensus Statement
In one paragraph

Review in Vox sanguinis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Review
  3. Article
  4. Diagnosis and management of iron deficiency in females.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. SucrosomialPharmaceuticals (Basel, Switzerland) · 2023
    Review
  15. Article
  16. Article
  17. Hypersensitivity to Intravenous Iron Preparations.Children (Basel, Switzerland) · 2022
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Wendy LimDepartment of Medicine, Division of Hematology and Thromboembolism, St. Joseph's Healthcare Hamilton, McMaster University, Hamilton, ON, Canada.ORCID https://orcid.org/0000-0003-2508-1786
Waqqas AfifDepartment of Medicine, Division of Gastroenterology and Hepatology, Montreal General Hospital, McGill University, Montreal, QC, Canada.
Sandra KnowlesDepartment of Pharmacy, Division of Clinical Pharmacology and Toxicology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Gloria LimDepartment of Medicine, Division of Hematology and Oncology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Yulia LinDepartment of Laboratory Medicine and Molecular Diagnostics, Division of Clinical Pathology, Sunnybrook Health Sciences Centre, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-5562-9020
Charmaine MothersillDepartment of Medicine, Division of Hematology and Oncology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Irina NistorDepartment of Gastroenterology and Hepatology, Halton Healthcare Services, Oakville, ON, Canada.
Faisal RehmanDepartment of Medicine, Division of Nephrology, University Hospital, London Health Sciences Centre, Western University, London, ON, Canada.
Christine SongDepartment of Medicine, Division of Allergy and Immunology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Ted XenodemetropoulosDepartment of Medicine, Division of Gastroenterology, McMaster University Medical Centre, McMaster University, Hamilton, ON, Canada.
St. Michael's Hospital · CASunnybrook Health Science Centre · CAMcMaster University Medical Centre · CAMontreal General Hospital · CAQueen's University · CASt. Joseph’s Healthcare Hamilton · CAWestern University · CA

Funding

Pfizer Canada
6 · The paper itself

Abstract

BACKGROUND AND

objectivesRare but potentially life-threatening hypersensitivity reactions can occur during the administration of intravenous iron. To provide guidance to healthcare professionals caring for adults receiving intravenous iron, a panel of 10 Canadian clinical experts developed a practical algorithm for the identification and management of hypersensitivity reactions to intravenous iron. MATERIALS AND

methodsA systematic search of PubMed to February 2018 was performed. Articles related to hypersensitivity reactions were selected for review. The algorithm was developed during a 1-day live meeting based on the literature review and clinical expertise where evidence was lacking. The algorithm was then refined through an iterative process involving a web-based platform and virtual meetings.

resultsThe algorithm provides guidance to healthcare professionals in preparing for and administering IV iron, as well as recognizing and managing hypersensitivity reactions to intravenous iron. Considerations for re-challenging patients who have experienced prior reactions are provided.

conclusionHealthcare professionals who are involved in the care of patients receiving intravenous iron should be trained to anticipate, recognize and manage hypersensitivity reactions to intravenous iron to optimize patient care.

Indexed as

AdultAlgorithmsAnaphylaxisCanadaConsensusFemaleHematologyHumansHypersensitivityInfusions, IntravenousInternetIronMalePatient SafetyQuality of Health CareSocieties, Medicalferryl ironIronanaphylaxisconsensushypersensitivity reactionsintravenous iron

Identifiers

PMID30937914
PMCPMC6850285
OpenAlexW2928467061

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.