Evidence map›Paper›PMID 30937731›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2019

The impact of progressive chronic kidney disease on health-related quality-of-life: a 12-year community cohort study.

Melanie L R Wyld, Rachael L Morton, Phil Clayton, Muh Geot Wong, Meg Jardine, Kevan Polkinghorne, Steve Chadban

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Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Melanie L R WyldSydney Medical School, University of Sydney, Sydney, NSW, Australia. Melanie.Wyld@health.nsw.gov.au.ORCID http://orcid.org/0000-0001-9250-107X
Rachael L MortonNHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.
Phil ClaytonRoyal Adelaide Hospital, Adelaide, Australia.
Muh Geot WongThe George Institute for Global Health, Sydney, NSW, Australia.
Meg JardineThe George Institute for Global Health, Sydney, NSW, Australia.
Kevan PolkinghorneMonash Medical Centre and Monash University, Clayton, VIC, Australia.
Steve ChadbanSydney Medical School, University of Sydney, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeQuality-of-life is poor in end-stage kidney disease; however, the relationships between earlier stages of chronic kidney disease (CKD) and are poorly understood. This study explored longitudinal quality-of-life changes in a community-based CKD cohort and assessed associations between CKD and quality-of-life over time, and between baseline quality-of-life and CKD outcomes.

methodsWe used the Australian diabetes, obesity and lifestyle study-a nationally representative, prospective cohort with data collected at baseline, year 5 and year 12-to examine the relationships between CKD stage, quality-of-life and outcomes. Linear mixed regression, cox proportional hazards, Kaplan-Meier and competing risks analyses were used.

resultsOf 1112 participants with CKD and baseline quality-of-life data, the physical component summary (PCS) score was significantly lower than for the general population (p = 0.01 age and sex adjusted), while the mental component summary (MCS) score was no different (p = 0.9 age and sex adjusted). In our unadjusted mixed effects model, more advanced kidney disease was associated with lower PCS and higher MCS at baseline (p < 0.001 and p < 0.01, respectively); however, this effect was no longer significant after adjustment for demographic and clinical variables. The rate of decline in PCS over the period of follow-up was greatest for those with more advanced kidney disease (p < 0.001 in unadjusted model, p = 0.007 in adjusted model). There was no association between change in MCS over the period of follow-up and severity of kidney disease in either the unadjusted or adjusted model (p = 0.7 and p = 0.1, respectively). Lower PCS, but not MCS, was associated with increased cardiovascular and increased all-cause mortality even after adjustment for key demographic and clinical variables (p < 0.001).

conclusionsPhysical, but not mental, quality-of-life is significantly impaired in CKD, and continues to decline with disease progression.

Indexed as

Health StatusAdultAgedAustraliaCohort StudiesDiabetes MellitusDisease ProgressionFemaleHumansKidney Failure, ChronicLongitudinal StudiesMaleMiddle AgedProspective StudiesQuality of LifeRenal Insufficiency, ChronicAUSDIABCKDQuality-of-lifeSF36

Identifiers

PMID30937731

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.