ArticleMolecular biology reports2019
Antioxidant activities of α-lipoic acid free and nano-capsule inhibit the growth of Ehrlich carcinoma.
Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Antitumor effects of Dadas Cress (Lepidium sativum var. sativum) on Ehrlich Ascites tumor cells: an in vitro and in vivo study.Journal of molecular histology · 2025Article
- Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic.Antioxidants (Basel, Switzerland) · 2024Review
- Efficacy of iron-silver bimetallic nanoparticles to enhance radiotherapy.Naunyn-Schmiedeberg's archives of pharmacology · 2023Article
- Physico-chemical properties of curcumin nanoparticles and its efficacy against Ehrlich ascites carcinoma.Scientific reports · 2023Article
- Magnetic fields enhance the anti-tumor efficacy of low dose cisplatin and reduce the nephrotoxicity.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Genome-Protecting Compounds as Potential Geroprotectors.International journal of molecular sciences · 2020Review
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2 authors at 1 institution in 1 country.
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Abstract
To evaluate the relationship between oxidative stress, DNA damage, and suppression of tumor growth induced by lipoic acid free and nano-capsule. Lipoic acid nano-capsule was assessed by transmission electron microscopy (TEM). The antitumor activity of lipoic acid free and nano-capsule was investigated in Ehrlich solid tumor bearing mice. The endpoints measured were superoxide dismutase (SOD) enzyme activity, malondialdehyde (MDA) levels, DNA damage (comet assay), histopathological examination of tissues and tumor growth volume. Treatment with α-lipoic acid (A-LA) free and nano-capsule (1.2, 2.4 mg/kg) showed a significant depression (67-28%) in MDA levels and elevated (38-98%) in SOD activity. Additionally, A-LA free and nano-capsule caused a 3-10-fold increase in comet parameters such as % tail DNA and suppressed Ehrlich solid tumor growth in mice. In conclusion, the present study revealed that A-LA free and nano-capsule have antitumor activity. This might be possible via its redox activity.
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