ArticleMetabolomics : Official journal of the Metabolomic Society2019
Disturbed energy and amino acid metabolism with their diagnostic potential in mitral valve disease revealed by untargeted plasma metabolic profiling.
Article in Metabolomics : Official journal of the Metabolomic Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Circulating Biomarkers Related to Mitral Valve Prolapse: Current Evidence and Mechanistic Perspective.Current cardiology reports · 2026Review
- Recent advances in omics-based research of mitral valve disease.Frontiers in cardiovascular medicine · 2026Review
- A retrospective analysis of the prognostic implications of glycemic variability on all-cause mortality in critically ill patients with mitral valve disease.Frontiers in endocrinology · 2025Article
- Review
- Article
- High-Throughput Metabolomics Applications in Pathogenesis and Diagnosis of Valvular Heart Disease.Reviews in cardiovascular medicine · 2023Review
- The Gut Microbiome Dynamically Associates with Host Glucose Metabolism throughout Pregnancy: Longitudinal Findings from a Matched Case-Control Study of Gestational Diabetes Mellitus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- The first taxonomic and functional characterization of human CAVD-associated microbiota.Microbial cell (Graz, Austria) · 2023Article
- Urinary Metabolomics Study of Patients with Bicuspid Aortic Valve Disease.Molecules (Basel, Switzerland) · 2021Article
- Metabolomics Analysis Reveals Deranged Energy Metabolism and Amino Acid Metabolic Reprogramming in Dogs With Myxomatous Mitral Valve Disease.Journal of the American Heart Association · 2021Article
- Untargeted Metabolomics Reveals Major Differences in the Plasma Metabolome between Colorectal Cancer and Colorectal Adenomas.Metabolites · 2021Article
- A comparison of high-throughput plasma NMR protocols for comparative untargeted metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Systems Metabolic Alteration in a Semi-Dwarf Rice Mutant Induced byInternational journal of molecular sciences · 2020Article
- Formate metabolism in health and disease.Molecular metabolism · 2020Review
- Serum untargeted metabolomic changes in response to diet intervention in dogs with preclinical myxomatous mitral valve disease.PloS one · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMitral valve disease (MVD), including mitral valve regurgitation (MR) and mitral valve stenosis (MS), is a chronic and progressive cardiac malady. However, the metabolic alterations in MVD is not well-understood till now. The current gold standard diagnostic test, transthoracic echocardiography, has limitations on high-throughput measurement and lacks molecular information for early diagnosis of the disease.
objectiveThe present study aimed to investigate the biochemical alterations and to explore their diagnostic potential for MVD.
methodsPlasma metabolic profile derangements and their diagnostic potential were non-invasively explored in 34 MR and 20 MS patients against their corresponding controls, using high-throughput NMR-based untargeted metabolomics.
resultsEighteen differential metabolites were identified for MR and MS patients respectively, on the basis of multivariate and univariate data analysis, which were mainly involved in energy metabolism, amino acid metabolism, calcium metabolism and inflammation. These differential metabolites, notably the significantly down-regulated formate and lactate, showed high diagnostic potential for MVD by using Spearman's rank-order correlation analysis and ROC analysis.
conclusionsTo the best of our knowledge, the present study is the first one that explores the metabolic derangements and their diagnostic values in MVD patients using metabolomics. The findings indicated that metabolic disturbance occurred in MVD patients, with plasma formate and lactate emerged as important candidate biomarkers for MVD.
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