ArticleACS central science2019
Molecular Basis of Broad Spectrum
Open access · diamondAbstract read
In one paragraph
Article in ACS central science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Article
- Efficient Preparation of Homogenous Antibody Conjugates via Glycosite-Specific Transglycosylation Enabled by Readily Available Glycosyl Donors.Angewandte Chemie (International ed. in English) · 2026Article
- Asymmetrically glycosylated IgG1 antibodies are universal and drive human disease.Nature communications · 2025Article
- The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases.Nature communications · 2025Article
- Cell-based glycoengineering for production of homogeneous and specific glycoform-enriched antibodies with improved effector functions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Article
- Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers.Science advances · 2024Article
- Immunomodulating Enzymes fromMicroorganisms · 2024Review
- Modulating antibody effector functions by Fc glycoengineering.Biotechnology advances · 2023Review
- Turning universal O into rare Bombay type blood.Nature communications · 2023Article
- Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases.Nature communications · 2023Article
- Mass Spectrometry-Based Methods to Determine the Substrate Specificities and Kinetics of N-Linked Glycan Hydrolysis by Endo-β-N-Acetylglucosaminidases.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS.Nature communications · 2022Article
- Endoglycosidase assay using enzymatically synthesized fluorophore-labeled glycans as substrates to uncover enzyme substrate specificities.Communications biology · 2022Article
- Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems.Chemical reviews · 2022Review
- Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE.Nature communications · 2022Article
- Sculpting therapeutic monoclonal antibody N-glycans using endoglycosidases.Current opinion in structural biology · 2022Review
- GH18 endo-β-N-acetylglucosaminidases use distinct mechanisms to process hybrid-type N-linked glycans.The Journal of biological chemistry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 3 countries.
Erik H KlontzInstitute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Beatriz TrastoyStructural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Spain.
Daniel DeredgeDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States.
James K FieldsInstitute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Chao LiDepartment of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
Jared OrwenyoDepartment of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
Alberto MarinaStructural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Spain.
Robert BeadenkopfInstitute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Sebastian GüntherInstitute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Jair FloresInstitute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Patrick L WintrodeDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States.
Lai-Xi WangDepartment of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States.
Marcelo E GuerinStructural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Spain.
Eric J SundbergInstitute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
University of Maryland, Baltimore · USUniversity of Maryland, College Park · USCIC bioGUNE · ESIkerbasque · ES
Funding
X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6MSignaling Pathways in Innate ImmunityT32AI095190 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Stefanie N. Vogel · 2012 to 2026
$4.7MCovergent Chemoenzymatic Synthesis of Glycopeptides and GlycoproteinsR01GM080374 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI WANG, LAI-XI · 2007 to 2021
$3.9MSynthesis and Function of Antibody Fc Domain GlycoformsR01GM096973 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI WANG, LAI-XI · 2011 to 2020
$2.4MNIAID NIH HHS T32 AI095190NIGMS NIH HHS P41 GM103393NIGMS NIH HHS R01 GM080374NIGMS NIH HHS R01 GM096973
Abstract
Immunoglobulin G (IgG) glycosylation critically modulates antibody effector functions.
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.