ArticleACS central science2019
Acoustic Droplet Ejection Enabled Automated Reaction Scouting.
Article in ACS central science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- High-throughput reaction screening using acoustic ejection mass spectrometry.Nature protocols · 2026Review
- Frugal Sampling Strategies for Navigating Complex Reaction Spaces.Organic process research & development · 2026Article
- Direct-to-Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery.ChemMedChem · 2026Review
- Frontier Technologies in Single-Cell Analysis: Synergistic Fusion of Droplet Printing and High-Performance Detection System.Analytical science advances · 2025Review
- High-Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15-Specific Protease mUSP18.Angewandte Chemie (International ed. in English) · 2025Article
- A Comprehensive Review of Surface Acoustic Wave-Enabled Acoustic Droplet Ejection Technology and Its Applications.Micromachines · 2023Review
- High-Throughput Purification in Drug Discovery: Scaling New Heights of Productivity.ACS medicinal chemistry letters · 2023Review
- Innovations and Inventions: Why Was the Ugi Reaction Discovered Only 37 Years after the Passerini Reaction?The Journal of organic chemistry · 2023Review
- A Brief Introduction to Chemical Reaction Optimization.Chemical reviews · 2023Review
- 'Chemistry at the speed of sound': automated 1536-well nanoscale synthesis of 16 scaffolds in parallel.Green chemistry : an international journal and green chemistry resource : GC · 2023Article
- High-Throughput Platform for Novel Reaction Discovery.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Optimization of Covalent MKK7 InhibitorsJournal of medicinal chemistry · 2022Article
- Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale.Nature communications · 2022Article
- Combining High-Throughput Synthesis and High-Throughput Protein Crystallography for Accelerated Hit Identification.Angewandte Chemie (International ed. in English) · 2021Article
- Isoquinolone-4-Carboxylic Acids by Ammonia-Ugi-4CR and Copper-Catalyzed Domino Reaction.The Journal of organic chemistry · 2021Article
- Nanoscale, automated, high throughput synthesis and screening for the accelerated discovery of protein modifiers.RSC medicinal chemistry · 2021Article
- Multicomponent reaction-derived covalent inhibitor space.Science advances · 2021Article
- Diverse Isoquinoline Scaffolds by Ugi/Pomeranz-Fritsch and Ugi/Schlittler-Müller Reactions.Organic letters · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Miniaturization and acceleration of synthetic chemistry are critically important for rapid property optimization in pharmaceutical, agrochemical, and materials research and development. However, in most laboratories organic synthesis is still performed on a slow, sequential, and material-consuming scale and not validated for multiple substrate combinations. Herein, we introduce fast and touchless acoustic droplet ejection (ADE) technology into small-molecule chemistry to transfer building blocks by nL droplets and to scout a newly designed isoquinoline synthesis. With each compound in a discrete well, 384 random derivatives were synthesized in an automated fashion, and their quality was monitored by SFC-MS and TLC-UV-MS analysis. We exemplify a pipeline of fast and efficient nmol scouting to mmol- and mol-scale synthesis for the discovery of a useful novel reaction with great scope.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.