ArticleACS central science2019
3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body.
Article in ACS central science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Endovascular magnetic filters for removing excess chemotherapeutic drugs from blood flow using dimensionless scaling laws.Bioengineering & translational medicine · 2026Article
- Carboxyl Dissociation Degree (Macromolecules · 2026Article
- 3D Printed Biosponge Adsorbers for Capturing Toxic Chemotherapy DrugsACS biomaterials science & engineering · 2026Article
- 3D Printing in Oral Drug Delivery: Technologies, Clinical Applications and Future Perspectives in Precision Medicine.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Dihydroartemisinin inhibits melanoma migration and metastasis by affecting angiogenesis.Phytotherapy research : PTR · 2025Article
- Trends in Photopolymerization 3D Printing for Advanced Drug Delivery Applications.Biomacromolecules · 2025Review
- Enhanced Hemodynamics of Anisometric TPMS Topology Reduce Blood Clotting in 3D Printed Blood Contactors.Advanced healthcare materials · 2025Article
- The therapeutic effect and MR molecular imaging of FA-PEG-FePt/DDP nanoliposomes in AMF on ovarian cancer.International journal of nanomedicine · 2024Article
- Evaluating Radioactive Analogs of Doxorubicin to Quantify ChemoFilter Binding and Whole-Body Positron Emission Tomography/Magnetic Resonance Imaging for Drug Biodistribution.Journal of vascular and interventional radiology : JVIR · 2022Article
- 3D printed elastomers with Sylgard-184-like mechanical properties and tuneable degradability.Polymer chemistry · 2022Article
- Article
- Engineering hairy cellulose nanocrystals for chemotherapy drug capture.Materials today. Chemistry · 2022Article
- Scalable 3D-printed lattices for pressure control in fluid applications.AIChE journal. American Institute of Chemical Engineers · 2021Article
- 3D-Printed Drug Capture Materials Based on Genomic DNA Coatings.ACS applied materials & interfaces · 2021Article
- ATP-responsive near-infrared fluorescence MOF nanoprobe for the controlled release of anticancer drug.Mikrochimica acta · 2021Article
- Aldehyde-Functionalized Magnetic Particles to Capture Off-Target Chemotherapeutic Agents.ACS omega · 2020Article
- Computational modeling of drug transport and mixing in the chemofilter device: enhancing the removal of chemotherapeutics from circulation.Biomechanics and modeling in mechanobiology · 2020Article
- Modeling iontophoretic drug delivery in a microfluidic device.Lab on a chip · 2020Article
- Fabricating Mechanically Robust Binder-Free Structured Zeolites by 3D Printing Coupled with Zeolite Soldering: A Superior Configuration for COAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Digital manufacturing of advanced materials: challenges and perspective.Materials today (Kidlington, England) · 2019Article
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
Abstract
Despite efforts to develop increasingly targeted and personalized cancer therapeutics, dosing of drugs in cancer chemotherapy is limited by systemic toxic side effects. We have designed, built, and deployed porous absorbers for capturing chemotherapy drugs from the bloodstream after these drugs have had their effect on a tumor, but before they are released into the body where they can cause hazardous side effects. The support structure of the absorbers was built using 3D printing technology. This structure was coated with a nanostructured block copolymer with outer blocks that anchor the polymer chains to the 3D printed support structure and a middle block that has an affinity for the drug. The middle block is polystyrenesulfonate which binds to doxorubicin, a widely used and effective chemotherapy drug with significant toxic side effects. The absorbers are designed for deployment during chemotherapy using minimally invasive image-guided endovascular surgical procedures. We show that the introduction of the absorbers into the blood of swine models enables the capture of 64 ± 6% of the administered drug (doxorubicin) without any immediate adverse effects. Problems related to blood clots, vein wall dissection, and other biocompatibility issues were not observed. This development represents a significant step forward in minimizing toxic side effects of chemotherapy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.