Evidence map›Paper›PMID 30937350›Full record

ReviewNeurobiology of stress2019

Child maltreatment and the development of substance use and disorder.

Dante Cicchetti, Elizabeth D Handley

Abstract readReview
In one paragraph

Review in Neurobiology of stress, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dante CicchettiInstitute of Child Development, University of Minnesota, USA.
Elizabeth D HandleyMt. Hope Family Center, University of Rochester, USA.

Funding

Chronic Stress of Maltreatment: Drug Use VulnerabilityR01DA017741 · NIDA · UNIVERSITY OF ROCHESTER · PI CICCHETTI, DANTE CICCHETTI, ROGOSCH, FRED A · 2004 to 2016
$5.1M
TEEN DRUG USE/ABUSE: PATHWAYS FROM CHILD MALTREATMENTR01DA012903 · NIDA · UNIVERSITY OF ROCHESTER · PI CICCHETTI, DANTE · 2000 to 2004
$2.2M
NIDA NIH HHS R01 DA012903NIDA NIH HHS R01 DA017741
6 · The paper itself

Abstract

Children who experience maltreatment are at well-documented risk for the development of problematic substance use and disorder in adolescence and beyond. This review applies a developmental psychopathology framework to discuss the complex multilevel probabilistic pathways from child maltreatment to substance use and substance use disorder (SUD). We begin with an overview of the myriad vulnerabilities associated with child maltreatment, including the development of substance use and SUD. Prominent pathways that may potentiate liability for SUD are discussed. Specifically, we highlight the robust empirical support for the prominent externalizing pathway of risk, and also discuss the state of the research regarding the internalizing pathway. Consistent with the developmental psychopathology perspective, we then review biological processes such as neuroendrocrine mechanisms, allostatic load, and neurobiological pathways that may underlie child maltreatment risk, as well as discuss broader contextual issues. Elucidating the processes underlying the development of substance use and disorder among children exposed to this form of early adversity is paramount for not only informing developmental theories, but also designing effective prevention and intervention programs. Thus, implications for preventive interventions are provided. Finally, critical next steps for research within the area of child maltreatment and the developmental psychopathology of substance use and SUD are proffered.

Indexed as

Child maltreatmentDevelopmental cascadesMultiple levels of analysisPrevention and interventionSubstance useSubstance use disorder

Identifiers

PMID30937350
PMCPMC6430405

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.