Evidence map›Paper›PMID 30937156›Full record

ArticleTherapeutic advances in chronic disease2019

Randomized controlled trial: a pilot study of a psychoeducational intervention for fatigue in patients with quiescent inflammatory bowel disease.

Anthony O'Connor, Raguprakash Ratnakumaran, Lisa Warren, Debbie Pullen, Anna Errington, David J Gracie, Rebecca C Sagar, P John Hamlin, Alexander C Ford

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in chronic disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Psychological interventions for treatment of inflammatory bowel disease.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Pooled it
  3. Interventions for fatigue in inflammatory bowel disease.The Cochrane database of systematic reviews · 2020
    Pooled it
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Anthony O'ConnorDepartment of Gastroenterology, Tallaght University Hospital, Belgard Road, Tallaght, Dublin D24NR0A, Ireland Leeds Gastroenterology Institute, St. James' University Hospital, Leeds, UK Tallaght Hospital/Trinity College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0003-1722-4820
Raguprakash RatnakumaranLeeds Gastroenterology Institute, St. James' University Hospital, Leeds, UK.
Lisa WarrenLeeds Gastroenterology Institute, St. James' University Hospital, Leeds, UK.
Debbie PullenLeeds and York Partnership NHS Foundation Trust, Leeds General Infirmary, Leeds, UK.
Anna ErringtonLeeds and York Partnership NHS Foundation Trust, Leeds General Infirmary, Leeds, UK.
David J GracieLeeds Gastroenterology Institute, St. James' University Hospital, Leeds, UK.
Rebecca C SagarLeeds Gastroenterology Institute, St. James' University Hospital, Leeds, UK.
P John HamlinLeeds Gastroenterology Institute, St. James' University Hospital, Leeds, UK.
Alexander C FordLeeds Gastroenterology Institute, St. James' University Hospital, Leeds, UK.
University of Leeds · GBLeeds General Infirmary · GBSt James's University Hospital · GBTrinity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFatigue is a frequent, debilitating symptom of inflammatory bowel disease (IBD). Despite this, studies report dissatisfaction among IBD patients regarding how little attention is given to fatigue-related issues during consultations. We performed a pilot randomized controlled trial (RCT) to assess whether a brief, structured, multidisciplinary psychological support program improved fatigue, mood and quality of life indices in patients with quiescent IBD.

methodsThe intervention consisted of three small-group psychoeducational sessions over 6 months. Primary outcomes were effect on fatigue severity and impact scores. Secondary outcomes included effect on depression, anxiety, somatization scores, generic and disease-specific quality of life.

resultsTwenty-three patients were enrolled, 10 in the intervention arm and 13 controls. Mean fatigue severity and impact scores improved for patients in the intervention group (by 14.5-13.1 and 49.7-45.8, respectively), and worsened in controls (by 11.5-12.6 and 33.5-35 respectively). Mean Short Form 36 (SF-36) scores for role limitations due to physical health decreased from 44.4 to 38.9 in the intervention group, but increased from 44.2 to 51.9 among controls. Energy scores in the intervention group improved from 17.8 to 26.6, but only from 31.4 to 31.7 among controls. Short IBD questionnaire scores improved in both groups, from 46.2 to 45.2 in controls compared with 44.4-40 in the intervention group. DISCUSSION: In this small pilot RCT, positive effects were demonstrated on fatigue, energy levels and other quality of life outcomes. Larger, adequately powered studies with longer follow up are required.

Indexed as

Crohn’s diseasefatigueinflammatory bowel diseasequality of lifeulcerative colitis

Identifiers

PMID30937156
PMCPMC6435872
OpenAlexW2925001634

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.