Evidence map›Paper›PMID 30937128›Full record

ArticleThe World Allergy Organization journal2019

Under-diagnosis of atopic dermatitis in Puerto Rican children.

Ge Yang, Yueh-Ying Han, Erick Forno, Edna Acosta-Pérez, Angel Colón-Semidey, María Alvarez, Glorisa Canino, Wei Chen, Juan C Celedón

Open access · goldAbstract read
In one paragraph

Article in The World Allergy Organization journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Ge YangDivision of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Yueh-Ying HanDivision of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Erick FornoDivision of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Edna Acosta-PérezBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Angel Colón-SemideyBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
María AlvarezBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Glorisa CaninoBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Wei ChenDivision of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Juan C CeledónDivision of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Children's Hospital of Pittsburgh · USUniversity of Puerto Rico System · PRCentral South University · CN

Funding

Epigenetic Variation and Childhood Asthma in Puerto RicansR01HL117191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2013 to 2020
$5.8M
NHLBI NIH HHS R01 HL117191
6 · The paper itself

Abstract

backgroundLittle is known about atopic dermatitis (AD) among children in Puerto Rico.

objectiveTo examine risk factors and identify approaches to better diagnose AD in Puerto Rican children.

methodsCase-control study of AD among 540 children aged 6-14 years in San Juan, Puerto Rico. AD was defined as: 1) physician-diagnosed AD, 2) RAST-AD: AD symptoms plus ≥1 positive IgE to allergens, and 3) STR-AD: AD-symptoms and skin test reactivity to ≥1 allergen. Logistic regression was used for the multivariable analysis. We also evaluated the diagnostic performance of various approaches by comparing their sensitivity, specificity, positive predicted value [PPV], negative predictive value [NPV], and area under curve [AUC]).

resultsOf the 70 children with STR-AD, only 5 (7.1%) had PD-AD. In children without asthma, a positive IgE to Dermatophagoides (D.) pteronyssinus and signs of mold/mildew at home were significantly associated with 3.3 and 5 times increased odds of STR-AD, respectively. Among children with asthma, private/employer-based health insurance and a positive IgE to D. pteronyssinus were each significantly associated with approximately twofold increased odds of STR-AD. A combination of current eczema symptoms and a positive IgE to

conclusionsAD is markedly under-diagnosed by physicians in Puerto Rico. This could be improved by assessing eczema symptoms and measuring IgEs to common allergens.

Indexed as

AD, Atopic dermatitisAtopic dermatitisAUC, Area under curveBMI, Body mass indexChildrenNPV, Negative predictive valuePD-AD, Physician diagnosed atopic dermatitisPPV, Positive predictive valuePuerto RicoRAST, Radioallergosorbent testROC, Receiver operating curveSTR-AD, Skin test reactivity atopic dermatitisSTR, Skin test reactivityUnder-diagnosis

Identifiers

PMID30937128
PMCPMC6439410
OpenAlexW2913194828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.