Evidence map›Paper›PMID 30936941›Full record

ArticleBiotechnology for biofuels2019

Modulation of acetate utilization in

Qin Xu, Chenxiao Bai, Yiqi Liu, Lili Song, Lin Tian, Yunfeng Yan, Jinfeng Zhou, Xiangshan Zhou, Yuanxing Zhang, Menghao Cai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biotechnology for biofuels, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
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  5. Second generation Pichia pastoris strain and bioprocess designs.Biotechnology for biofuels and bioproducts · 2022
    Review
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Qin Xu1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237 China.
Chenxiao Bai1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237 China.
Yiqi Liu1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237 China.
Lili Song1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237 China.
Lin Tian1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237 China.
Yunfeng Yan1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237 China.
Jinfeng Zhou1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237 China.
Xiangshan Zhou1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237 China.
Yuanxing Zhang1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237 China.
Menghao Cai1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237 China.ORCID 0000-0001-6225-8515
East China University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcetate, an economical industrial chemical, which is also the precursor of acetyl-CoA, could serve as an alternative substrate for biomanufacturing. This nontraditional substrate can be widely produced from syngas via hydrolysis or pyrolysis of the cellulosic biomass, chemical or microbial catalysis, anaerobic fermentation in treated wastewater, etc. However, the toxicity of acetate to microorganisms has held back its utilization, especially for the eukaryotes that are good hosts for production of complicated pharmaceuticals or chemicals. This study seeks to improve acetate utilization in a widely used yeast host,

resultsA kinase-deficient library of

conclusions

Indexed as

Acetate utilizationAcetyl-CoAKinase screeningKomagataella phaffiiMetabolic engineering

Identifiers

PMID30936941
PMCPMC6427870
OpenAlexW2935819102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.