Evidence map›Paper›PMID 30936938›Full record

ArticleChinese medicine2019

Identifying the functions and biomarkers of

Pin-Hao Ko, Chiung-Wei Huang, Hen-Hong Chang, Eric Y Chuang, Mong-Hsun Tsai, Liang-Chuan Lai

Open access · goldAbstract read
In one paragraph

Article in Chinese medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Therapeutic potential ofInternational journal of medical sciences · 2025
    Article
  3. Network Pharmacology Integrated with Transcriptomics Deciphered the Potential Mechanism ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  4. Effect of miR-488 on Colon Cancer Biology and Clinical Applications.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Pin-Hao Ko1Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, 100 Taiwan.
Chiung-Wei Huang2Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807 Taiwan.
Hen-Hong Chang3School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung, 404 Taiwan.
Eric Y Chuang5Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, 106 Taiwan.
Mong-Hsun Tsai6Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, 100 Taiwan.
Liang-Chuan Lai1Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, 100 Taiwan.ORCID 0000-0002-3913-5338
National Taiwan University · TWChina Medical University · TWKaohsiung Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHomeostasis is a crucial concept used to describe the condition of patients and the roles of herbs in traditional Chinese medicine. Qi-deficiency pattern is one of the conditions when loss of homeostasis and is usually characterized by symptoms including lassitude, spontaneous sweating, and a weak pulse, which are not easy to quantitate.

methodsAqueous extracts of crude qi-tonifying herbs,

resultsA total of 67 differentially expressed probes that responded to both herbs were identified. A pathway analysis revealed that these genes were involved in the development, growth, movement, and viability of the liver cells.

conclusionsAfter qRT-PCR validation and examination of clinical data from public domains, our results showed that two genes,

Indexed as

Astragalus membranaceusBiomarkersCitrus reticulateCodonopsis pilosulaHepG2

Identifiers

PMID30936938
PMCPMC6425643
OpenAlexW2937950765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.