Evidence map›Paper›PMID 30936896›Full record

ArticleJournal of otology2019

Chronic model of tympanic perforation in rats with mitomycin C and dexamethasone.

Tomás Esteban, Noemí M Atucha, José María Moraleda, Joaquín García-Estañ, Carmen L Insausti, Javier Moraleda-Deleyto

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of otology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Tomás EstebanServicio de Otorinolaringología, Hospital General Universitario Santa Lucía, Cartagena, Spain.
Noemí M AtuchaDepartamento de Fisiología, Facultad de Medicina, Universidad de Murcia, Instituto Murciano de Investigación Biosanitaria, 30120, El Palmar, Murcia, Spain.
José María MoraledaDepartamento de Medicina, Facultad de Medicina, Universidad de Murcia, Instituto Murciano de Investigación Biosanitaria, 30120, El Palmar, Murcia, Spain.
Joaquín García-EstañDepartamento de Fisiología, Facultad de Medicina, Universidad de Murcia, Instituto Murciano de Investigación Biosanitaria, 30120, El Palmar, Murcia, Spain.
Carmen L InsaustiDepartamento de Medicina, Facultad de Medicina, Universidad de Murcia, Instituto Murciano de Investigación Biosanitaria, 30120, El Palmar, Murcia, Spain.
Javier Moraleda-DeleytoENT Service, University Hospital of Lewisham, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A rat model of chronic tympanic membrane perforation was developed to be used in the search of new materials for the sealing of these perforations. A longitudinal study was carried out in rats subjected to incisional myringotomy followed by the application of mitomycin C alone or with dexamethasone. Rats were checked at days 3, 7, 10, 14 and weekly thereafter until perforation closure, for up to 6 months. The addition of dexamethasone is a key component in order to obtain a chronic opening. Myringotomies treated with saline had a mean healing time of 8.5 days. At 8 weeks, between 62.5% and 77.7% of tympanic membranes treated with mitomycin C and dexamethasone remained perforated and at 6 months this number fell to 21.4%. This technique is able to maintain most tympanic membrane perforations patent for at least 8 weeks. This rat model is adequate for its use in preclinical or translational research.

Indexed as

Animal modelChronic tympanic membrane perforationDexamethasoneMitomycin CMyringotomy

Identifiers

PMID30936896
PMCPMC6424699

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.