Evidence map›Paper›PMID 30936881›Full record

ArticleFrontiers in immunology2019

LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking.

Marcin Łyszkiewicz, Daniel Kotlarz, Natalia Ziȩtara, Gudrun Brandes, Jana Diestelhorst, Silke Glage, Elias Hobeika, Michael Reth, Lukas A Huber, Andreas Krueger and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  4. Essential role of MFSD1-GLMP-GIMAP5 in lymphocyte survival and liver homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Marcin ŁyszkiewiczInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Daniel KotlarzDepartment of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Natalia ZiȩtaraInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Gudrun BrandesInstitute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Germany.
Jana DiestelhorstDepartment of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Silke GlageInstitute of Laboratory Animal Science, Hannover Medical School, Hannover, Germany.
Elias HobeikaInstitute of Immunology, Ulm University, Ulm, Germany.
Michael RethMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Lukas A HuberDivision of Cell Biology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Andreas KruegerInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Christoph KleinDepartment of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Ludwig-Maximilians-Universität München · DEMedizinische Hochschule Hannover · DEInnsbruck Medical University · ATMax Planck Institute of Immunobiology and Epigenetics · DEUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B-cell development and function depend on stage-specific signaling through the B-cell antigen receptor (BCR). Signaling and intracellular trafficking of the BCR are connected, but the molecular mechanisms of this link are incompletely understood. Here, we investigated the role of the endosomal adaptor protein and member of the LAMTOR/Ragulator complex LAMTOR2 (p14) in B-cell development. Efficient conditional deletion of LAMTOR2 at the pre-B1 stage using

Indexed as

AnimalsB-LymphocytesCalcium SignalingCell DivisionDNA-Binding ProteinsEndosomesLymphocyte ActivationLymphopoiesisMiceMice, Inbred C57BLMice, KnockoutMicroscopy, Electron, TransmissionProteinsProtein TransportReceptors, Antigen, B-CellSignal TransductionDNA-Binding ProteinsLAMTOR2 protein, mouseProteinsRag2 protein, mouseReceptors, Antigen, B-CellB-cell antigen receptorB cellsLAMTOR2p14signal transductiontrafficking

Identifiers

PMID30936881
PMCPMC6431647
OpenAlexW2921828299

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.