Evidence map›Paper›PMID 30936879›Full record

ArticleFrontiers in immunology2019

Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8

Zhengqi Wang, Tamisha Y Vaughan, Wandi Zhu, Yuhong Chen, Guoping Fu, Magdalena Medrzycki, Hikaru Nishio, Silvia T Bunting, Pamela A Hankey-Giblin, Asma Nusrat and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Roles of Macrophages in the Development and Treatment of Gut Inflammation.Frontiers in cell and developmental biology · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Zhengqi WangDivision of Hem/Onc/BMT, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA, United States.
Tamisha Y VaughanDivision of Hem/Onc/BMT, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA, United States.
Wandi ZhuDivision of Hem/Onc/BMT, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA, United States.
Yuhong ChenBloodCenter of Wisconsin, Milwaukee, WI, United States.
Guoping FuBloodCenter of Wisconsin, Milwaukee, WI, United States.
Magdalena MedrzyckiDivision of Hem/Onc/BMT, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA, United States.
Hikaru NishioDepartment of Pathology, Emory University, Atlanta, GA, United States.
Silvia T BuntingDepartment of Pathology, Children's Healthcare of Atlanta, Atlanta, GA, United States.
Pamela A Hankey-GiblinDepartment of Veterinary Science, Pennsylvania State University, University Park, PA, United States.
Asma NusratDepartment of Pathology, Emory University, Atlanta, GA, United States.
Charles A ParkosDepartment of Pathology, Emory University, Atlanta, GA, United States.
Demin WangBloodCenter of Wisconsin, Milwaukee, WI, United States.
Renren WenBloodCenter of Wisconsin, Milwaukee, WI, United States.
Kevin D BuntingDivision of Hem/Onc/BMT, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA, United States.
Emory University · USVersiti Blood Center of Wisconsin · USCenter for Cancer and Blood Disorders · USChildren's Healthcare of Atlanta · USPennsylvania State University · USUniversity of Michigan–Ann Arbor · US

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5M
Intestinal Mucosal Wound Resealing in IBDR01DK055679 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ASMA NUSRAT · 2004 to 2026
$8.1M
Neutrophil Interactions with Intestinal Epithelial CellsR01DK072564 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARKOS, CHARLES A · 2005 to 2020
$6.5M
B cell responses in heparin-induced thrombocytopeniaR01HL130724 · NHLBI · VERSITI WISCONSIN, INC. · PI WANG, DEMIN · 2017 to 2024
$4.8M
PLC?s in B cell biology and autoimmunityR01AI079087 · NIAID · VERSITI WISCONSIN, INC. · PI WANG, DEMIN · 2008 to 2018
$4.4M
STAT5 Structure-Function in HematopoiesisR01DK059380 · NIDDK · EMORY UNIVERSITY · PI BUNTING, KEVIN D · 2002 to 2017
$4.2M
INTESTINAL MUCOSAL WOUND RESEALING IN SURGICAL DISEASESR29DK055679 · NIDDK · EMORY UNIVERSITY · PI NUSRAT, ASMA · 1998 to 2002
$324k
NHLBI NIH HHS R01 HL130724NIAID NIH HHS R01 AI079087NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK055679NIDDK NIH HHS R01 DK059380NIDDK NIH HHS R01 DK072564NIDDK NIH HHS R29 DK055679
6 · The paper itself

Abstract

Inflammatory Bowel Disease (IBD) is a multi-factorial chronic inflammation of the gastrointestinal tract prognostically linked to CD8

Indexed as

Adaptor Proteins, Signal TransducingAdoptive TransferAnimalsCD8-Positive T-LymphocytesColitisDisease Models, AnimalInflammatory Bowel DiseasesIntraepithelial LymphocytesLipocalin-2Lymphocyte ActivationMacrophage ActivationMacrophagesMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicAdaptor Proteins, Signal TransducingGab2 protein, mouseGab3 protein, mouseLipocalin-2mTOR protein, mousePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesCD4+ T-cellcolitiseffector CD8+ T-cellGrb2-associated binding proteininflammatory bowel diseaseintraepithelial lymphocytemacrophage

Identifiers

PMID30936879
PMCPMC6431666
OpenAlexW2921158339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.