Evidence map›Paper›PMID 30936875›Full record

ArticleFrontiers in immunology2019

DNA Sensor IFI204 Contributes to Host Defense Against

Wei Chen, Shui-Xing Yu, Feng-Hua Zhou, Xiao-Jing Zhang, Wen-Ying Gao, Kun-Yu Li, Zhen-Zhen Liu, Wen-Yu Han, Yong-Jun Yang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. IFI204 RestrictsMicroorganisms · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Innate immune responses in pneumonia.Pneumonia (Nathan Qld.) · 2023
    Review
  11. Article
  12. Review
  13. Review
  14. Stimulator of Interferon Genes (STING) PromotesFrontiers in cell and developmental biology · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. STING Contributes to Host Defense AgainstFrontiers in immunology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wei ChenKey Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
Shui-Xing YuState Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China.
Feng-Hua ZhouKey Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
Xiao-Jing ZhangKey Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
Wen-Ying GaoInstitute of Translational Medicine, The First Hospital, Jilin University, Changchun, China.
Kun-Yu LiKey Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
Zhen-Zhen LiuKey Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
Wen-Yu HanKey Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
Yong-Jun YangKey Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
Jilin University · CNInner Mongolia University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interferon-inducible protein (IFI204) (p204, the murine homolog of human IFI16) is known as a cytosolic DNA sensor to recognize DNA viruses and intracellular bacteria. However, little is known about its role during extracellular bacterial infection. Here we show that IFI204 is required for host defense against the infection of

Indexed as

AnimalsBacteremiaBacterial LoadBone Marrow TransplantationChemokine CXCL1CytokinesDNA, BacterialFemaleInterferon-betaInterferon Regulatory Factor-3MacrophagesMacrophages, PeritonealMaleMembrane ProteinsMiceMice, Inbred C57BLChemokine CXCL1Cxcl1 protein, mouseCytokinesDNA, BacterialIfi16 protein, mouseInterferon-betaInterferon Regulatory Factor-3Irf3 protein, mouseMembrane ProteinsNF-kappa BNuclear ProteinsPhosphoproteinsRecombinant ProteinsSting1 protein, mouseSTING ProteinDNA sensorextracellular trapIFI16IFI204innate immunephagocytosisStaphylococcus aureus (MRSA)STING

Identifiers

PMID30936875
PMCPMC6431627
OpenAlexW2922220990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.