Evidence map›Paper›PMID 30936870›Full record

ArticleFrontiers in immunology2019

The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification.

Thibault Bouderlique, Lucia Peña-Pérez, Shabnam Kharazi, Miriam Hils, Xiaoze Li, Aleksandra Krstic, Ayla De Paepe, Christian Schachtrup, Charlotte Gustafsson, Dan Holmberg and 2 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Thibault BouderliqueDepartment of Laboratory Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Lucia Peña-PérezDepartment of Laboratory Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Shabnam KharaziDepartment of Laboratory Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Miriam HilsFaculty of Medicine & Faculty of Biology, Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, Freiburg, Germany.
Xiaoze LiDepartment of Laboratory Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Aleksandra KrsticDepartment of Laboratory Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Ayla De PaepeDepartment of Laboratory Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Christian SchachtrupFaculty of Medicine, Institute of Anatomy and Cell Biology, University of Freiburg, Freiburg, Germany.
Charlotte GustafssonDepartment of Laboratory Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Dan HolmbergLund University Diabetes Center, Lund University, Malmö, Sweden.
Kristina SchachtrupFaculty of Medicine & Faculty of Biology, Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, Freiburg, Germany.
Robert MånssonDepartment of Laboratory Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SEUniversity of Freiburg · DELund University · SEUniversity Medical Center Freiburg · DE

Funding

Swedish Cancer Foundation
6 · The paper itself

Abstract

The apparition of adaptive immunity in

Indexed as

Amino Acid SequenceAnimalsBasic Helix-Loop-Helix ProteinsBiological EvolutionCell LineageEvolution, MolecularGene DuplicationGene Expression RegulationHematopoiesisHematopoietic Stem CellsImmunity, HumoralLeukopoiesisLymphocyte SubsetsLymphoid Progenitor CellsMiceMice, Inbred C57BLBasic Helix-Loop-Helix ProteinsTcf12 protein, mouseTcf3 protein, mouseTcf4 protein, mouseTranscription Factor 4E-proteinevolutionhematopoiesishumoral immunitylymphoid specification

Identifiers

PMID30936870
PMCPMC6433000
OpenAlexW2952034057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.