Evidence map›Paper›PMID 30936868›Full record

ArticleFrontiers in immunology2019

High-Dose Dexamethasone Alters the Increase in Interleukin-16 Level in Adult Immune Thrombocytopenia.

Xinru Wang, Lizhen Li, Yuanjian Wang, Xin Li, Qi Feng, Yu Hou, Chunhong Ma, Chengjiang Gao, Ming Hou, Jun Peng

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Xinru WangDepartment of Haematology and Qilu Hospital, Shandong University, Jinan, China.
Lizhen LiShandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Shandong University, Jinan, China.
Yuanjian WangWest China School of Medicine, Sichuan University, Jinan, China.
Xin LiShandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Shandong University, Jinan, China.
Qi FengDepartment of Haematology and Qilu Hospital, Shandong University, Jinan, China.
Yu HouDepartment of Haematology and Qilu Hospital, Shandong University, Jinan, China.
Chunhong MaDepartment of Immunology, Shandong University School of Medicine, Jinan, China.
Chengjiang GaoDepartment of Immunology, Shandong University School of Medicine, Jinan, China.
Ming HouShandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Shandong University, Jinan, China.
Jun PengDepartment of Haematology and Qilu Hospital, Shandong University, Jinan, China.
Qilu Hospital of Shandong University · CNShandong University · CNLiaocheng People's Hospital · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult primary immune thrombocytopenia (ITP) is an autoimmune-mediated haemorrhagic disorder. Interleukin-16 (IL-16) can directly affect cellular or humoural immunity by mediating the cellular cross-talk among T cells, B cells and dendritic cells. Several studies have focused on IL-16 as an immunomodulatory cytokine that takes part in Th1 polarization in autoimmune diseases. In this study, we investigated IL-16 expression in the bone marrow supernatant and plasma of ITP patients and healthy controls. What's more, we detected IL-16 expression in ITP patients with the single-agent 4-day high-dose dexamethasone (HD-DXM) therapy. In patients with active ITP, bone marrow supernatant and plasma IL-16 levels increased (

Indexed as

AdultBone MarrowCase-Control StudiesCaspase 3DexamethasoneDose-Response Relationship, DrugFemaleGene Expression RegulationHumansImmunosuppressive AgentsInterleukin-16Leukocytes, MononuclearMaleMiddle AgedPurpura, Thrombocytopenic, IdiopathicRNA, MessengerCASP3 protein, humanCaspase 3DexamethasoneIl16 protein, humanImmunosuppressive AgentsInterleukin-16RNA, MessengerT-bet Transcription FactorT-Box Domain Proteinsadult immune thrombocytopeniacaspase-3high-dose dexamethasoneInterleukin-16Th1 polarization

Identifiers

PMID30936868
PMCPMC6431608
OpenAlexW2922247606

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.