ReviewFrontiers in neuroscience2019
Electromagnetic Brain Stimulation in Patients With Disorders of Consciousness.
Review in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Repetitive transcranial magnetic stimulation targeting the dorsolateral prefrontal cortex promotes recovery of consciousness in patients with disorders of consciousness: a meta-analysis of randomized controlled trials.Journal of neurology · 2025Pooled it
- Best Evidence Summary for the Improvement and Management of Disorders of Consciousness in Patients With Severe Brain Injury.Brain and behavior · 2025Pooled it
- Effect of transcranial direct current stimulation for patients with disorders of consciousness: A systematic review and meta-analysis.Frontiers in neuroscience · 2022Pooled it
- Sleep patterns correlates with the efficacy of tDCS on post-stroke patients with prolonged disorders of consciousness.Journal of translational medicine · 2022Trial
- Preliminary Study of Vagus Nerve Magnetic Modulation in Patients with Prolonged Disorders of Consciousness.Neuropsychiatric disease and treatment · 2022Trial
- Advances in understanding and treating disorders of consciousness caused by brainstem injury.Chinese neurosurgical journal · 2025Review
- Pleasant odors specifically promote a soothing autonomic response and brain-body coupling through respiratory modulation.Scientific reports · 2025Article
- Targeting the parietal memory network with tDCS in MCI: study protocol for a randomized controlled trial.Frontiers in human neuroscience · 2025Article
- Efficacy of repetitive transcranial magnetic stimulation for disorders of consciousness: a retrospective cohort study.Frontiers in neurology · 2025Article
- Utilizing Centromedian Thalamus Connectivity to Personalize Noninvasive Neuromodulation Targets.CNS neuroscience & therapeutics · 2024Article
- Cognitive Effects of Transcranial Direct Current Stimulation Plus Robotic Verticalization in Minimally Conscious State.Biomedicines · 2024Article
- Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness.Communications biology · 2024Article
- Optogenetic Brain-Computer Interfaces.Bioengineering (Basel, Switzerland) · 2024Review
- Differences in the effect of repetitive transcranial magnetic stimulation and median nerve electrical stimulation in patients with prolonged disorders of consciousness after intracerebral hemorrhage: a randomized controlled trial protocol.Frontiers in neurology · 2024Article
- Article
- Transplantation of glutamatergic neuronal precursor cells in the paraventricular thalamus and claustrum facilitates awakening with recovery of consciousness.CNS neuroscience & therapeutics · 2023Article
- Clinical Decision on Disorders of Consciousness After Acquired Brain Injury: Stepping Forward.Neuroscience bulletin · 2023Review
- Current status and prospect of transcutaneous auricular vagus nerve stimulation for disorders of consciousness.Frontiers in neuroscience · 2023Review
- Clinical effect of short-term spinal cord stimulation in the treatment of patients with primary brainstem hemorrhage-induced disorders of consciousness.Frontiers in neurology · 2023Article
- Safety and therapeutic effects of personalized transcranial direct current stimulation based on electrical field simulation for prolonged disorders of consciousness: study protocol for a multi-center, double-blind, randomized controlled trial.Frontiers in neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe brain injury is a common cause of coma. In some cases, despite vigilance improvement, disorders of consciousness (DoC) persist. Several states of impaired consciousness have been defined, according to whether the patient exhibits only reflexive behaviors as in the vegetative state/unresponsive wakefulness syndrome (VS/UWS) or purposeful behaviors distinct from reflexes as in the minimally conscious state (MCS). Recently, this clinical distinction has been enriched by electrophysiological and neuroimaging data resulting from a better understanding of the physiopathology of DoC. However, therapeutic options, especially pharmacological ones, remain very limited. In this context, electroceuticals, a new category of therapeutic agents which act by targeting the neural circuits with electromagnetic stimulations, started to develop in the field of DoC. We performed a systematic review of the studies evaluating therapeutics relying on the direct or indirect electro-magnetic stimulation of the brain in DoC patients. Current evidence seems to support the efficacy of deep brain stimulation (DBS) and non-invasive brain stimulation (NIBS) on consciousness in some of these patients. However, while the latter is non-invasive and well tolerated, the former is associated with potential major side effects. We propose that all chronic DoC patients should be given the possibility to benefit from NIBS, and that transcranial direct current stimulation (tDCS) should be preferred over repetitive transcranial magnetic stimulation (rTMS), based on the literature and its simple use. Surgical techniques less invasive than DBS, such as vagus nerve stimulation (VNS) might represent a good compromise between efficacy and invasiveness but still need to be further investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.