Evidence map›Paper›PMID 30936675›Full record

ArticleJournal of orthopaedics

Overlapping features of rapidly progressive osteoarthrosis and Charcot arthropathy.

Takashi Sono, Carolyn A Meyers, Daniel Miller, Catherine Ding, Edward F McCarthy, Aaron W James

Open access · bronzeAbstract read
In one paragraph

Article in Journal of orthopaedics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Does Advanced Osteoarthritis Mimic Neuropathic Joint?Indian journal of orthopaedics · 2025
    Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Takashi SonoDepartment of Pathology, Johns Hopkins University, Ross Research Building, Room 524A, 720 Rutland Avenue, Baltimore, MD, 21205, United States.
Carolyn A MeyersDepartment of Pathology, Johns Hopkins University, Ross Research Building, Room 524A, 720 Rutland Avenue, Baltimore, MD, 21205, United States.
Daniel MillerDepartment of Pathology, Johns Hopkins University, Ross Research Building, Room 524A, 720 Rutland Avenue, Baltimore, MD, 21205, United States.
Catherine DingDepartment of Pathology, Johns Hopkins University, Ross Research Building, Room 524A, 720 Rutland Avenue, Baltimore, MD, 21205, United States.
Edward F McCarthyDepartment of Pathology, Johns Hopkins University, Ross Research Building, Room 524A, 720 Rutland Avenue, Baltimore, MD, 21205, United States.
Aaron W JamesDepartment of Pathology, Johns Hopkins University, Ross Research Building, Room 524A, 720 Rutland Avenue, Baltimore, MD, 21205, United States.
Johns Hopkins University · USKyoto University · JP

Funding

Direct and indirect contributions of perivascular stem cells to bone healingR01AR070773 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI JAMES, AARON W · 2017 to 2021
$1.4M
NELL-1 isoforms for the systemic treatment of osteoporosisK08AR068316 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JAMES, AARON W · 2015 to 2019
$534k
Role of sensory nerves in cranial bone repairR21DE027922 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI CLEMENS, THOMAS L, JAMES, AARON W · 2018 to 2019
$450k
NIAMS NIH HHS K08 AR068316NIAMS NIH HHS R01 AR070773NIDCR NIH HHS R21 DE027922
6 · The paper itself

Abstract

Nerve growth factor (NGF) is the primary neurotrophin in the skeleton and a central mediator of skeletal pain. Recent trials of anti-NGF neutralizing antibodies have resulted in infrequent but well-described incidence of rapidly progressive osteoarthrosis (RPOA). Neuropathy, whether from syphilis or diabetes, is also associated with severe joint destruction, known as neuroarthropathy or Charcot joint. These commonalities of severe joint destruction with either loss of a neurotrophin (anti-NGF) or a deficit of functional skeletal innervation led us to examine our institutional case files for potential radio-pathologic overlap between RPOA and Charcot joint.

Indexed as

Charcot jointNeuropathic arthropathyRapidly progressive osteoarthrosis

Identifiers

PMID30936675
PMCPMC6426701
OpenAlexW2921339820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.