ArticleNature reviews. Neurology2019
Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond.
Article in Nature reviews. Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 99 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Integrating AI with Biosensors and Voltammetry for Neurotransmitter Detection and Quantification: A Systematic Review.Biosensors · 2025Pooled it
- Battery-free, fully wireless neurostimulation via radiative RF power transfer in freely behaving mice.Microsystems & nanoengineering · 2026Article
- Closed-loop transcranial alternating current stimulation (tACS) reduces cue reactivity and improves inhibitory control in methamphetamine use disorder with frequency and timing specificity.Molecular psychiatry · 2026Article
- Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.Nature medicine · 2026Article
- From continuous to adaptive deep brain stimulation: Personalized modulation improves motor complications and sleep in Parkinson's Disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- AI-based discovery of functional boundaries in the human brain from intraoperative electrophysiology.medRxiv : the preprint server for health sciences · 2026Article
- Cortical and basal ganglia beta oscillations and frequency-dependent DBS effects in the A53T Parkinson's disease rat model.NPJ Parkinson's disease · 2026Article
- Article
- Artificial intelligence as a surrogate brain: bridging neural dynamical models and data.National science review · 2026Review
- Bayesian Temporal Prediction: A Robust Algorithm for Real-Time EEG Phase-Dependent Brain Stimulation.IEEE transactions on bio-medical engineering · 2026Article
- Deep Brain Stimulation as a Rehabilitation Amplifier: A Precision-Oriented, Network-Guided Framework for Functional Restoration in Movement Disorders.Journal of clinical medicine · 2026Review
- Facile Deep Brain Electrode Coating with MXene for Improved Electrode Performance.Advanced healthcare materials · 2026Article
- Cellular and Molecular Mechanisms of Neuroprotection in Deep Brain Stimulation for Parkinson's Disease.Biomedicines · 2025Review
- Cortical and Corticomuscular Beta-Gamma Phase-Amplitude Coupling During Different Locomotion States and the Effects of Levodopa in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Subthalamic Electrophysiological Mapping of Gait Initiation Dynamics and Freezing in Parkinson's Disease.Annals of neurology · 2025Article
- The medial septum-hippocampus-lateral septum circuitry in spatial memory: linking healthy function to early Alzheimer's disease and translational opportunities.Translational neurodegeneration · 2025Review
- Polypyrrole Coatings as Possible Solutions for Sensing and Stimulation in Bioelectronic Medicines.Biosensors · 2025Article
- Implantable Self-Powered Systems for Electrical Stimulation Medical Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Subthalamic stimulation evokes hyperdirect high beta interruption and cortical high gamma entrainment in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Flexible graphene-based neurotechnology for high-precision deep brain mapping and neuromodulation in Parkinsonian rats.Nature communications · 2025Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subthalamic deep brain stimulation (DBS) for Parkinson disease (PD) currently requires laborious open-loop programming, which can mitigate the benefits of this treatment. Experimental closed-loop DBS systems are emerging that can sense the electrophysiological surrogates of PD motor signs and respond with delivery of an automatically adapted stimulation. Such biomarker-based neural interfaces constitute a major advance towards improving the outcomes of patients treated with DBS and enhancing our understanding of the pathophysiological mechanisms underlying PD. In this Perspectives article, we argue that closed-loop DBS, in addition to offering advantages in patients with PD, might extend the current indications for DBS to include selected psychiatric disorders in which the symptoms are similarly driven by pathological brain circuit activity. The success of closed-loop DBS in such settings will depend on the identification of symptom-specific biomarkers, which ideally should reflect causal mechanisms of the underlying pathology.
Indexed as
Identifiers
30936569What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.