SynthesisNature medicine2019
Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer.
3 registry-linked trialsAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 801 papers, 10 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
801citing papers in PubMed, 10 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis
NCT04223102 naactive not recruitingnot on this mapstarted 2020, after this paper: background citation
Rectal Microbiome Variability Among Rectal Cancer Cohorts Including Complete Clinical Responders, Pathologic Responders, and Early Recurrence
Comprehensive Analysis of Gut Microbiota Signatures in Metastatic Colorectal Cancer
Who cites it
801 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- The Hidden Link Between Intestinal Helminthiasis, Gut Microbiome Alterations, and Colorectal Cancer Risk: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Global research trends inFrontiers in cellular and infection microbiology · 2026Pooled it
- Engineered bacteria and engineered probiotics for intestinal disease therapy: a bibliometric and knowledge mapping analysis.Frontiers in microbiology · 2026Pooled it
- Meta-analysis of 22,710 human microbiome metagenomes defines an oral-to-gut microbial enrichment score and associations with host health and disease.Nature communications · 2025Pooled it
- Machine Learning Models To Characterize the Association of the Gut Microbiota with Osteopenia and Osteoporosis: A Multi-Cohort Study.Current microbiology · 2025Pooled it
- Artificial intelligence at the gut-oral microbiota frontier: mapping machine learning tools for gastric cancer risk prediction.Biomedical engineering online · 2025Pooled it
- Pooled it
- Melody: meta-analysis of microbiome association studies for discovering generalizable microbial signatures.Genome biology · 2025Pooled it
- Meta-analysis of gut microbiome reveals patterns of dysbiosis in colorectal cancer patients.Journal of medical microbiology · 2025Pooled it
- Cross-cohort analysis identifies shared gut microbial signatures and validates microbial risk scores for colorectal cancer.Journal of translational medicine · 2025Pooled it
- Beyond Taxonomy: Fungal Nutraceutical Supplementation Modifies the Functional Potential of the Gut Microbiome in Colorectal Cancer.International journal of molecular sciences · 2026Trial
- Decoding the microbiome: artificial intelligence-targeted gut microenvironment breakthroughs in personalized cancer therapy.Gut microbes · 2026Review
- The role of adhesins ofGut microbes · 2026Review
- Pangenome analysis reveals both niche-specific "specialists" and microbial "side hustlers" in colorectal cancer microbiomes.Gut microbes · 2026Article
- Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis.Gut microbes · 2026Review
- Colorectal cancer landscape from gut microbiota: Insights into mutations, epigenetic dysregulation, and immune microenvironment alterations.Virulence · 2026Review
- Identifying low-quality features and suboptimal models to enhance phenotype prediction.Patterns (New York, N.Y.) · 2026Article
- Observational
- Fusobacterium nucleatum enhances enterotoxigenic Bacteroides fragilis-mediated neuron loss and intestinal motility dysfunction.Nature microbiology · 2026Article
- Review
741 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
35 authors.
Jakob Wirbel *Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4073-3562
Paul Theodor Pyl *Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-7651-883X
Ece KartalStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Konrad ZychStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-7426-0516
Alireza KashaniNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark.
Alessio MilaneseStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7050-2239
Jonas S FleckStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Anita Y VoigtStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Albert PallejaNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5388-4063
Ruby PonnuduraiStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Shinichi SunagawaStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-3065-0314
Luis Pedro CoelhoStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Petra Schrotz-KingDivision of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-4339-3492
Emily VogtmannDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Nina HabermannGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Emma NiméusDivision of Surgery, Oncology and Pathology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.
Andrew M ThomasDepartment CIBIO, University of Trento, Trento, Italy.ORCID http://orcid.org/0000-0001-5789-3354
Paolo ManghiDepartment CIBIO, University of Trento, Trento, Italy.
Sara GandiniIEO, European Institute of Oncology IRCCS, Milan, Italy.ORCID http://orcid.org/0000-0002-1348-4548
Davide SerranoIEO, European Institute of Oncology IRCCS, Milan, Italy.
Sayaka MizutaniSchool of Life Science and Technology, Tokyo Institute of Technology, Tokyo, Japan.
Hirotsugu ShiromaSchool of Life Science and Technology, Tokyo Institute of Technology, Tokyo, Japan.
Satoshi ShibaDivision of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
Tatsuhiro ShibataDivision of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0477-210X
Shinichi YachidaDivision of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
Takuji YamadaSchool of Life Science and Technology, Tokyo Institute of Technology, Tokyo, Japan.
Levi WaldronGraduate School of Public Health and Health Policy, City University of New York, New York, NY, USA.ORCID http://orcid.org/0000-0003-2725-0694
Alessio NaccaratiItalian Institute for Genomic Medicine, Turin, Italy.ORCID http://orcid.org/0000-0001-5774-0905
Nicola SegataDepartment CIBIO, University of Trento, Trento, Italy.ORCID http://orcid.org/0000-0002-1583-5794
Rashmi SinhaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Cornelia M UlrichHuntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.
Hermann BrennerDivision of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany.
Manimozhiyan ArumugamNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark. arumugam@sund.ku.dk.ORCID http://orcid.org/0000-0002-0886-9101
Peer BorkStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. bork@embl.de.ORCID http://orcid.org/0000-0002-2627-833X
Georg ZellerStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. zeller@embl.de.ORCID http://orcid.org/0000-0003-1429-7485
Funding
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6MTransdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare StudyU01CA206110 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jane C. Figueiredo, Christopher I Li · 2016 to 2026
$18.6MLower Gastrointestinal Cancer StudiesZIACP010198 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SINHA, RASHMI · 2009 to 2025
$6.6MDiscovery and verification of novel biomarkers of colorectal cancer recurrenceR01CA189184 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LI, CHRISTOPHER I, ULRICH, CORNELIA M · 2015 to 2020
$5.6MMetabolomic Strategies for Discovery and Validation of Biomarkers of Colorectal Cancer RecurrenceR01CA207371 · NCI · UNIVERSITY OF UTAH · PI LI, CHRISTOPHER I, ULRICH, CORNELIA M · 2017 to 2022
$3.9MEuropean Research Council 268985European Research Council 669830European Research Council 716575Intramural NIH HHS ZIA CP010198NCI NIH HHS P30 CA042014NCI NIH HHS R01 CA189184NCI NIH HHS R01 CA207371NCI NIH HHS U01 CA206110NIH HHS P30 CA042014NIH HHS R01 CA189184NIH HHS R01 CA207371NIH HHS U01 CA206110
Abstract
Association studies have linked microbiome alterations with many human diseases. However, they have not always reported consistent results, thereby necessitating cross-study comparisons. Here, a meta-analysis of eight geographically and technically diverse fecal shotgun metagenomic studies of colorectal cancer (CRC, n = 768), which was controlled for several confounders, identified a core set of 29 species significantly enriched in CRC metagenomes (false discovery rate (FDR) < 1 × 10
Indexed as
MetagenomeAdenomaAgedBiomarkers, TumorCohort StudiesColorectal NeoplasmsDatabases, GeneticFecesFemaleGastrointestinal MicrobiomeHumansMaleMiddle AgedModels, BiologicalReproducibility of ResultsSpecies SpecificityBiomarkers, Tumor
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.