ArticleNature chemistry2019
Prebiotic phosphorylation of 2-thiouridine provides either nucleotides or DNA building blocks via photoreduction.
Article in Nature chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 81 citations in OpenAlex.
- Impact of 2'-deoxyribo-purine substrates on nonenzymatic RNA template-directed primer extension.Nucleic acids research · 2025Article
- Nonenzymatic RNA copying with a potentially primordial genetic alphabet.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Thioesters Support Efficient Protein Biosynthesis by the Ribosome.ACS central science · 2025Article
- Synthesis and applications of cyclonucleosides: an update (2010-2023).Molecular diversity · 2024Review
- Protocellular Heme and Iron-Sulfur Clusters.Accounts of chemical research · 2024Review
- Unusual Base Pair between Two 2-Thiouridines and Its Implication for Nonenzymatic RNA Copying.Journal of the American Chemical Society · 2024Article
- The protometabolic nature of prebiotic chemistry.Chemical Society reviews · 2023Review
- Nucleoside Analogs: A Review of Its Source and Separation Processes.Molecules (Basel, Switzerland) · 2023Review
- Peptide conjugates with polyaromatic hydrocarbons can benefit the activity of catalytic RNAs.Chemical science · 2023Article
- Towards a prebiotic chemoton - nucleotide precursor synthesis driven by the autocatalytic formose reaction.Chemical science · 2023Article
- Article
- Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors.RNA (New York, N.Y.) · 2023Article
- Methyl Metabolism and the Clock: An Ancient Story With New Perspectives.Journal of biological rhythms · 2022Article
- Formation of the Codon Degeneracy during Interdependent Development between Metabolism and Replication.Genes · 2021Article
- Diamidophosphate (DAP): A Plausible Prebiotic Phosphorylating Reagent with a Chem to BioChem Potential?Chembiochem : a European journal of chemical biology · 2021Review
- Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders.Antioxidants (Basel, Switzerland) · 2021Review
- Prebiotic Photochemical Coproduction of Purine Ribo- and Deoxyribonucleosides.Journal of the American Chemical Society · 2021Article
- Radicals in Biology: Your Life Is in Their Hands.Journal of the American Chemical Society · 2021Article
- Timescales for Prebiotic Photochemistry Under Realistic Surface Ultraviolet Conditions.Astrobiology · 2021Article
- 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions.Nature communications · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Breakthroughs in the study of the origin of life have demonstrated how some of the building blocks essential to biology could have been formed under various primordial scenarios, and could therefore have contributed to the chemical evolution of life. Missing building blocks are then sometimes inferred to be products of primitive biosynthesis, which can stretch the limits of plausibility. Here, we demonstrate the synthesis of 2'-deoxy-2-thiouridine, and subsequently 2'-deoxyadenosine and 2-deoxyribose, under prebiotic conditions. 2'-Deoxy-2-thiouridine is produced by photoreduction of 2,2'-anhydro-2-thiouridine, which is in turn formed by phosphorylation of 2-thiouridine-an intermediate of prebiotic RNA synthesis. 2'-Deoxy-2-thiouridine is an effective deoxyribosylating agent and may have functioned as such in either abiotic or proto-enzyme-catalysed pathways to DNA, as demonstrated by its conversion to 2'-deoxyadenosine by reaction with adenine, and 2-deoxyribose by hydrolysis. An alternative prebiotic phosphorylation of 2-thiouridine leads to the formation of its 5'-phosphate, showing that hypotheses in which 2-thiouridine was a key component of early RNA sequences are within the bounds of synthetic credibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.