ArticleNature chemical biology2019
Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides.
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Article in Nature chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
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Who cites it
48 citing papers in PubMed, 85 citations in OpenAlex.
- Article
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- A teichoic acid-like wall modification associated with immune suppression is socially regulated inmBio · 2026Article
- A conserved glycan motif induces broadly reactive functional antibodies against the zoonotic pathogenScience advances · 2026Article
- A teichoic acid-like wall modification associated with immune suppression is socially regulated inbioRxiv : the preprint server for biology · 2026Article
- Editor's Choice Platform for identifying human glycan-specific antibodies against bacterial pathogens using synthetic glycan fragments.Glycobiology · 2025Article
- No compelling evidence that vaccination with streptococcus pyogenes group A carbohydrate elicits cross-reactive rheumatic fever autoantibodies.NPJ vaccines · 2025Review
- Isotype conversion of Staphylococcal-specific IgG into IgM broadens the reactivity to other bacterial pathogens.Cell reports. Medicine · 2025Article
- Discovery of glycerol phosphate and an immunogenic glycan motif in rhamnose-rich polysaccharides of Streptococcus uberis.Veterinary research · 2025Article
- Natural variation of the streptococcal group A carbohydrate biosynthesis genes impacts host-pathogen interaction.Microbial genomics · 2025Article
- Glycosylation of serine/threonine-rich intrinsically disordered regions of membrane-associated proteins in streptococci.Nature communications · 2025Article
- Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide.Nature communications · 2025Article
- Recombinant production platform for Group A Streptococcus glycoconjugate vaccines.NPJ vaccines · 2025Article
- Structure of a Sulfated Capsular Polysaccharide from the Marine BacteriumMarine drugs · 2025Article
- Review
- Pangenome evaluation of gene essentiality inMicrobiology spectrum · 2024Article
- Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota.Nature communications · 2024Article
- Review
- Sucrose-mediated formation and adhesion strength ofBiofilm · 2023Article
- Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host-microbe interactions with oral commensals.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 7 institutions in 6 countries.
Rebecca J EdgarDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA.
Vincent P van HensbergenDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Alessandro RudaDepartment of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-5918-5797
Andrew G TurnerAustralian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.ORCID http://orcid.org/0000-0003-0882-7881
Pan DengDivision of Cardiovascular Medicine and the Gill Heart Institute, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0003-2974-7389
Yoann Le BretonDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0001-8040-2605
Najib M El-SayedDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0001-7970-3312
Ashton T BelewDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0001-6725-5081
Kevin S McIverDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0002-4769-4463
Alastair G McEwanAustralian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Andrew J MorrisDivision of Cardiovascular Medicine and the Gill Heart Institute, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0003-1910-4865
Gérard LambeauUniversité Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne Sophia Antipolis, France.ORCID http://orcid.org/0000-0002-9239-518X
Mark J WalkerAustralian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
Jeffrey S RushDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA.
Konstantin V KorotkovDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0002-2182-6843
Göran WidmalmDepartment of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-8303-4481
Nina M van SorgeDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. nsorge3@umcutrecht.nl.ORCID http://orcid.org/0000-0002-2695-5863
Natalia KorotkovaDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA. nkorotkova@uky.edu.ORCID http://orcid.org/0000-0002-8696-4892
University of Kentucky · USUniversity of Maryland, College Park · USThe University of Queensland · AUStockholm University · SEUtrecht University · NLCentre National de la Recherche Scientifique · FRUniversity of Kentucky HealthCare · US
Funding
X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6MThe role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2012 to 2017
$13.7MPRD-Containing Virulence Regulators of Pathogenic StreptococciR01AI047928 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI MCIVER, KEVIN S. · 2001 to 2023
$6.5MPilot Projects ProgramP30GM127211 · NIGMS · UNIVERSITY OF KENTUCKY · PI PEARSON, KEVIN JOSEPH · 2018 to 2022
$5.7MProtein CoreP30GM110787 · NIGMS · UNIVERSITY OF KENTUCKY · PI MENDENHALL, MICHAEL D. · 2014 to 2018
$5.7MProfiling the Leishmania-macrophage Host-pathogen InfectomeR01AI094773 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI EL-SAYED, NAJIB M, MOSSER, DAVID M · 2011 to 2014
$2.5MBiogenesis and Function of Lancefield Group A Carbohydrate Expressed by Streptococcus PyogenesR56AI135021 · NIAID · UNIVERSITY OF KENTUCKY · PI KOROTKOVA, NATALIA · 2018 to 2018
$393kTriple Quadrupole Mass Spectrometer SystemS10OD021753 · OD · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 2017 to 2017
$352kNIAID NIH HHS R01 AI047928NIAID NIH HHS R01 AI094773NIAID NIH HHS R56 AI135021NIGMS NIH HHS P20 GM103527NIGMS NIH HHS P30 GM110787NIGMS NIH HHS P30 GM127211NIGMS NIH HHS P41 GM103393NIH HHS S10 OD021753
Abstract
Cell wall glycopolymers on the surface of Gram-positive bacteria are fundamental to bacterial physiology and infection biology. Here we identify gacH, a gene in the Streptococcus pyogenes group A carbohydrate (GAC) biosynthetic cluster, in two independent transposon library screens for its ability to confer resistance to zinc and susceptibility to the bactericidal enzyme human group IIA-secreted phospholipase A
Indexed as
GlycerolPhosphatesPolysaccharides, BacterialStreptococcusGlycerolPhosphatesPolysaccharides, Bacterial
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