ArticleNature microbiology2019
Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ.
Abstract read
In one paragraph
Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 105 citations in OpenAlex.
- Fecal microbiota transplantation reverses insulin resistance in type 2 diabetes: A randomized, controlled, prospective study.Frontiers in cellular and infection microbiology · 2022Trial
- Microbiota-dependent interferon-λ controls immunity of the uterus and maternal-fetal interface.Research square · 2026Article
- Flipping the script: Using mucosal immune obstacles to inform vaccine design.PLoS pathogens · 2026Article
- MDA5-MAVS and interferon-lambda signaling in the intestinal epithelium limit murine astrovirus infection.Mucosal immunology · 2026Article
- Microbiota-dependent IFN-L controls uterine and placental immunity.bioRxiv : the preprint server for biology · 2026Article
- Gut Virome and Aging: Phage-Driven Microbial Stability and Immune Modulation.Aging and disease · 2025Review
- Murine astrovirus infection course and antibody response in different mouse strains.Lab animal · 2025Article
- The gut virome in association with the bacteriome in gastrointestinal diseases and beyond: roles, mechanisms, and clinical applications.Precision clinical medicine · 2025Review
- Novel murine model of human astrovirus infection reveals cardiovascular tropismJournal of virology · 2025Article
- Sequential early-life viral infections modulate the microbiota and adaptive immune responses to systemic and mucosal vaccination.PLoS pathogens · 2024Article
- Regulation of host/pathogen interactions in the gastrointestinal tract by type I and III interferons.Current opinion in immunology · 2024Review
- Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis.Current opinion in immunology · 2024Review
- Article
- Exploring the Human Virome: Composition, Dynamics, and Implications for Health and Disease.Current microbiology · 2023Review
- Review
- Impact of the Microbiota on Viral Infections.Annual review of virology · 2023Review
- Chromosome folding and prophage activation reveal specific genomic architecture for intestinal bacteria.Microbiome · 2023Article
- Beyond pathogenesis: Detecting the full spectrum of ecological interactions in the virosphere.PLoS biology · 2023Article
- Review
- Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Harshad Ingle *Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Sanghyun Lee *Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-0736-1648
Teresa AiDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Anthony OrvedahlDepartment of Pediatrics, Washington University School of Medicine, Saint Louis, MO, USA.
Rachel RodgersDepartment of Pediatrics, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0001-7787-0491
Guoyan ZhaoDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Meagan SullenderDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Stefan T PetersonDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Marissa LockeDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-8086-9958
Ta-Chiang LiuDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Christine C YokoyamaDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
Bridgett SharpDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Stacey Schultz-CherryDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jonathan J MinerDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Megan T BaldridgeDepartment of Medicine, Washington University School of Medicine, Saint Louis, MO, USA. mbaldridge@wustl.edu.ORCID http://orcid.org/0000-0002-7030-6131
Washington University in St. Louis · USSt. Jude Children's Research Hospital · US
Funding
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MTRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8MMechanisms of STING-associated immunodeficiencyR01AI143982 · NIAID · WASHINGTON UNIVERSITY · PI Jonathan J Miner · 2019 to 2026
$4.6MRole of CD300 Family in Norovirus Tropism, Persistence, and ImmunityR01AI127552 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T, FREMONT, DAVED H. · 2017 to 2021
$3.5MSuppression of Enteric Norovirus Infection by Microbiota-Regulated Bile AcidsR01AI141478 · NIAID · UNIVERSITY OF FLORIDA · PI KARST, STEPHANIE M · 2019 to 2023
$2.7MNorovirus regulation via bacterial modulation of interferon-lambdaR01AI139314 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T · 2019 to 2023
$2.0MPediatric Infectious Diseases and Immunity Training ProgramT32AI106688 · NIAID · WASHINGTON UNIVERSITY · PI Megan Anne Cooper, DAVID HUNSTAD · 2014 to 2026
$1.9MContributions of IRF5 to Chikungunya Viral ArthritisK08AR070918 · NIAMS · WASHINGTON UNIVERSITY · PI MINER, JONATHAN J · 2017 to 2021
$612kDo they or don't they: astrovirus-induced diarrheaR21AI135254 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SCHULTZ-CHERRY, STACEY L · 2018 to 2019
$561kRegulation of Interferon-Lambda Signaling by Commensal Bacteria and NorovirusK22AI127846 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T · 2017 to 2018
$270kBeyond model development: murine astrovirus endogenous pathogens of laboratory miceR03AI126101 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SCHULTZ-CHERRY, STACEY L · 2016 to 2017
$179kNIAID NIH HHS K22 AI127846NIAID NIH HHS R01 AI127552NIAID NIH HHS R01 AI139314NIAID NIH HHS R01 AI141478NIAID NIH HHS R01 AI143982NIAID NIH HHS R03 AI126101NIAID NIH HHS R21 AI135254NIAID NIH HHS T32 AI007163NIAID NIH HHS T32 AI106688NIAMS NIH HHS K08 AR070918NIDDK NIH HHS P30 DK052574
Abstract
Commensal microbes profoundly impact host immunity to enteric viral infections
Indexed as
Immunocompromised HostAnimalsAstroviridaeCaliciviridae InfectionsFecal Microbiota TransplantationFecesFemaleGastroenteritisGastrointestinal TractInterferonsIntestinal MucosaMaleMiceNorovirusSignal TransductionVirus SheddingInterferons
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.