Evidence map›Paper›PMID 30936455›Full record

ArticleNature biomedical engineering2018

Micelles with ultralow critical micelle concentration as carriers for drug delivery.

Yang Lu, Zhanguo Yue, Jinbing Xie, Wei Wang, Hui Zhu, Ershuai Zhang, Zhiqiang Cao

Abstract read
In one paragraph

Article in Nature biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed.

  1. Article
  2. Therapeutic peptides and proteins: Status and developments in drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Pressure-Induced Ultralow Critical Micelle Concentration of Surfactant for Encapsulating Dye.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yang LuDepartment of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, USA.
Zhanguo YueDepartment of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, USA.
Jinbing XieDepartment of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, USA.
Wei WangDepartment of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, USA.
Hui ZhuDepartment of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, USA.
Ershuai ZhangDepartment of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, USA.
Zhiqiang CaoDepartment of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, USA. zcao@wayne.edu.

Funding

A Novel Formulation Enabling Longevity of Subcutaneous Insulin InfusionDP2DK111910 · NIDDK · WAYNE STATE UNIVERSITY · PI CAO, ZHIQIANG · 2016 to 2016
$1.3M
NIDDK NIH HHS DP2 DK111910
6 · The paper itself

Abstract

Conventional micellar carriers disassemble into free surfactants when diluted at concentrations below the critical micelle concentration (CMC). This limits the bioavailability in vivo of injected hydrophobic drugs encapsulated in micellar systems. Here, we show that a micelle comprising a superhydrophilic zwitterionic polymer domain and a superhydrophobic lipid domain has an undetectable CMC below 10

Indexed as

Drug CarriersMicellesAnimalsAntineoplastic AgentsDocetaxelHydrophobic and Hydrophilic InteractionsMelanoma, ExperimentalMiceMice, Inbred C57BLModels, MolecularRandom AllocationTissue DistributionAntineoplastic AgentsDocetaxelDrug CarriersMicelles

Identifiers

PMID30936455
PMCPMC6553490

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.