ArticleHeart (British Cardiac Society)2019
Risk factors for longitudinal changes in left ventricular diastolic function among women and men.
Article in Heart (British Cardiac Society), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Association of Cardiovascular Health and Genetic Risk for Left Ventricular Mass with Left Ventricular Structure, Function, and Incident Cardiovascular Outcomes.medRxiv : the preprint server for health sciences · 2026Article
- Longitudinal cardiac imaging for assessment of myocardial injury in non-hospitalised community-dwelling individuals after COVID-19 infection: the Rotterdam Study.Heart (British Cardiac Society) · 2025Article
- Epicardial Fat Volume, Cardiac Function, and Incident Heart Failure: The Rotterdam Study.Journal of the American Heart Association · 2023Article
- Mean and Variability of Lipid Measurements and Risk for Development of Subclinical Left Ventricular Diastolic Dysfunction.Diabetes & metabolism journal · 2022Article
- Association of estimated plasma volume status with hemodynamic and echocardiographic parameters.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- Objectives, design and main findings until 2020 from the Rotterdam Study.European journal of epidemiology · 2020Article
- HDL-C to hsCRP ratio is associated with left ventricular diastolic function in absence of significant coronary atherosclerosis.Lipids in health and disease · 2019Article
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10 authors.
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Abstract
objectiveTo evaluate changes in left ventricular diastolic function (LVDF) parameters and their associated risk factors over a period of 11 years among community-dwelling women and men.
methodsEchocardiography was performed three times among 870 women and 630 men (age 67±3 years) from the prospective population-based Rotterdam Study during a period of 11-year follow-up. Changes in six continuous LVDF parameters were correlated with cardiovascular risk factors using a linear-mixed effect model (LMM).
resultsIn women, smoking was associated with deleterious longitudinal changes in deceleration time (DT) (Beta (β): 7.73; 95% CI 2.56 to 12.9) and high-density lipoprotein cholesterol was associated with improvement of septal e' (β: 0.37; 95% CI 0.13 to 0.62) and E/e' ratio (β: -0.46; 95% CI -0.84 to -0.08) trajectories. Among men, diabetes was associated with deleterious longitudinal changes in A wave (β: 3.83; 95% CI 0.06 to 7.60), septal e' (β: -0.40; 95% CI -0.70 to -0.09) and E/e' ratio (β: 0.60; 95% CI 0.14 to 1.06) and body mass index was associated with deleterious longitudinal changes in A wave (β: 1.25; 95% CI 0.84 to 1.66), E/A ratio (β: -0.007; 95% CI -0.01 to -0.003), DT (β: 0.86; 95% CI 0.017 to 1.71) and E/e' ratio (β: 0.12; 95% CI 0.06 to 0.19).
conclusionsSmoking among women and metabolic factors (diabetes mellitus and body mass index) among men showed larger deleterious associations with longitudinal changes in LVDF parameters. The favourable association of HDL was mainly observed among women. This study, for the first time, evaluates risk factors associated with changes over time in continuous LVDF parameters among women and men and generates new hypothesis for further medical research.
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