Evidence map›Paper›PMID 30936351›Full record

ArticleBMJ case reports2019

Ocular infiltration as initial presentation of acute monocytic leukaemia transformed from chronic myelomonocytic leukaemia associated with

Aditya Tedjaseputra, Fathima Shahla Vilcassim, George Grigoriadis

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Aditya TedjaseputraDepartment of Clinical Haematology, Monash Health, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0001-6224-1940
Fathima Shahla VilcassimDepartment of Clinical Haematology, Monash Health, Clayton, Victoria, Australia.
George GrigoriadisDepartment of Clinical Haematology, Monash Health, Clayton, Victoria, Australia.
Hudson Institute of Medical Research · AUMonash Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute monocytic leukaemia (French-British-American classification: AML-M5b) is characterised by a predominance of cells of the monocytic lineage on bone marrow examination. Furthermore, a discerning feature is its tendency for tissue infiltration. While gum hypertrophy and hepatosplenomegaly are common, ocular involvement is rare. Here, we present a case of a 75-year-old man referred with proptosis and monocytosis-subsequently diagnosed as AML-M5b, whose disease course was distinguished by extensive tissue invasion (ocular, pulmonary, liver, spleen). Cytogenetics and molecular tests were consistent with blastic transformation of previously undiagnosed chronic myelomonocytic leukaemia, supported by the presence of long-standing, low-grade monocytosis. Notably, a

Indexed as

AgedAntimetabolites, AntineoplasticAzacitidineCell Transformation, NeoplasticExophthalmosFatal OutcomeHumansLeukemia, Monocytic, AcuteLeukemia, Myelomonocytic, ChronicLeukemic InfiltrationMaleMutationProto-Oncogene Proteins B-rafRetinaRetinal DiseasesAntimetabolites, AntineoplasticAzacitidineBRAF protein, humanProto-Oncogene Proteins B-rafcarcinogenesishaematology (incl blood transfusion)pathology

Identifiers

PMID30936351
PMCPMC6453331
OpenAlexW2929052522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.