Evidence map›Paper›PMID 30936241›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Glutamatergic Innervation onto Striatal Neurons Potentiates GABAergic Synaptic Output.

Foteini Paraskevopoulou, Melissa A Herman, Christian Rosenmund

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Foteini ParaskevopoulouDepartment of Neurophysiology, NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany.
Melissa A HermanDepartment of Neurophysiology, NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany.
Christian RosenmundDepartment of Neurophysiology, NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany christian.rosenmund@charite.de.ORCID 0000-0002-3905-2444
Charité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Striatal output pathways are known to play a crucial role in the control of movement. One possible component for shaping the synaptic output of striatal neuron is the glutamatergic input that originates from cortex and thalamus. Although reports focusing on quantifying glutamatergic-induced morphological changes in striatum exist, the role of glutamatergic input in regulating striatal function remains poorly understood. Using primary neurons from newborn mice of either sex in a reduced two-neuron microcircuit culture system, we examined whether glutamatergic input modulates the output of striatal neurons. We found that glutamatergic input enhanced striatal inhibition

Indexed as

2-Amino-5-phosphonovalerateAction PotentialsAnimalsAntibodies, NeutralizingBrain-Derived Neurotrophic FactorCells, CulturedCerebral CortexCorpus StriatumExcitatory Amino Acid AntagonistsFemaleGABAergic Neuronsgamma-Aminobutyric AcidGlutamic AcidInhibitory Postsynaptic PotentialsMaleMembrane Glycoproteins2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline2-Amino-5-phosphonovalerateAntibodies, NeutralizingBDNF protein, humanBdnf protein, mouseBrain-Derived Neurotrophic FactorExcitatory Amino Acid Antagonistsgamma-Aminobutyric AcidGlutamic AcidMembrane GlycoproteinsNtrk2 protein, mouseProtein-Tyrosine KinasesQuinoxalinesReceptor, trkBRecombinant ProteinsTetrodotoxinBDNFcell cultureexcitatory inputGABAergic neuronpaired recordingsstriatum

Identifiers

PMID30936241
PMCPMC6554626
OpenAlexW2933564878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.