Evidence map›Paper›PMID 30936239›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice.

Lynda El-Hassar, Lei Song, Winston J T Tan, Charles H Large, Giuseppe Alvaro, Joseph Santos-Sacchi, Leonard K Kaczmarek

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. KFrontiers in pharmacology · 2026
    Pooled it
  2. Optimization of Pyrazole-Based Activators of Kv3.1.ACS medicinal chemistry letters · 2026
    Article
  3. Presynaptic CabioRxiv : the preprint server for biology · 2026
    Article
  4. AProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Frontiers in cellular neuroscience · 2026
    Article
  7. Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  8. Review
  9. Input-Specific Organization of Intrinsic Excitability Expands Coding Capacity of Fast-Spiking Auditory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  10. Review
  11. Article
  12. Hyper-extralemniscal model of Fragile X syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Hyperacusis in the AdultInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 6 countries.

Lynda El-HassarDepartments of Pharmacology.
Lei SongSurgery.
Winston J T TanSurgery.ORCID 0000-0001-5418-8991
Charles H LargeAutifony Therapeutics Limited, Stevenage Bioscience Catalyst, Stevenage SG1 2FX, United Kingdom.
Giuseppe AlvaroAutifony Therapeutics Limited, Stevenage Bioscience Catalyst, Stevenage SG1 2FX, United Kingdom.
Joseph Santos-SacchiSurgery.ORCID 0000-0002-8274-7751
Leonard K KaczmarekDepartments of Pharmacology, leonard.kaczmarek@yale.edu.ORCID 0000-0001-5128-6326
Autifony Therapeutics (United Kingdom) · GBYale University · USInstitute of Pharmacology · CZShanghai Jiao Tong University · CN

Funding

EXPRESSION OF ION CHANNELS IN THE AUDITORY SYSTEMR01DC001919 · NIDCD · YALE UNIVERSITY · PI KACZMAREK, LEONARD K · 1993 to 2025
$9.7M
MEMBRANES PROPERTIES OF CELLS COMPRISING THE OHC SYSTEMR01DC000273 · NIDCD · YALE UNIVERSITY · PI SANTOS-SACCHI, JOSEPH R · 1989 to 2015
$6.8M
Membrane properties of the OHC systemR01DC016318 · NIDCD · YALE UNIVERSITY · PI DHASAKUMAR S NAVARATNAM, JOSEPH R SANTOS-SACCHI · 2017 to 2026
$6.7M
Structural correlates of prestin activity.R01DC008130 · NIDCD · YALE UNIVERSITY · PI NAVARATNAM, DHASAKUMAR S, SANTOS-SACCHI, JOSEPH R · 2007 to 2021
$6.1M
NIDCD NIH HHS R01 DC000273NIDCD NIH HHS R01 DC001919NIDCD NIH HHS R01 DC008130NIDCD NIH HHS R01 DC016318
6 · The paper itself

Abstract

Fragile X syndrome (FXS) is characterized by hypersensitivity to sensory stimuli, including environmental sounds. We compared the auditory brainstem response (ABR) recorded

Indexed as

AnimalsAuditory PathwaysAuditory PerceptionBrain StemCochlear NucleusElectrophysiological PhenomenaEvoked Potentials, Auditory, Brain StemFemaleFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeHydantoinsIn Vitro TechniquesMaleMiceMice, KnockoutPatch-Clamp TechniquesAUT2 compoundFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1HydantoinsKcnc1 protein, mousePyridinesShaw Potassium Channelsauditory brainstem responseAUT2fragile Xhigh- and low-threshold potassium channelsmedial nucleus of the trapezoid bodypotassium channels

Identifiers

PMID30936239
PMCPMC6561694
OpenAlexW2933026512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.