Evidence map›Paper›PMID 30936196›Full record

ArticleCold Spring Harbor molecular case studies2019

Genomic stratification and liquid biopsy in a rare adrenocortical carcinoma (ACC) case, with dual lung metastases.

Mark J McCabe, Mark Pinese, Chia-Ling Chan, Nisa Sheriff, Tanya J Thompson, John Grady, Marie Wong, Marie-Emilie A Gauthier, Clare Puttick, Velimir Gayevskiy and 12 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cold Spring Harbor molecular case studies, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. New strategies for applying targeted therapies to adrenocortical carcinoma.Current opinion in endocrine and metabolic research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 1 country.

Mark J McCabeKinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
Mark PineseKinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.ORCID 0000-0001-5078-6687
Chia-Ling ChanKinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
Nisa SheriffHormones and Cancer Group, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
Tanya J ThompsonHormones and Cancer Group, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
John GradyKinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
Marie WongKinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
Marie-Emilie A GauthierKinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
Clare PuttickKinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
Velimir GayevskiyKinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
Elektra HajduKinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
Stephen Q WongMolecular and Translational Genomics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.
Wade BarrettDepartment of Anatomical Pathology, St Vincent's Hospital, Sydney, New South Wales 2010, Australia.
Peter EarlsDepartment of Anatomical Pathology, St Vincent's Hospital, Sydney, New South Wales 2010, Australia.
Robyn LukeisDepartment of Anatomical Pathology, St Vincent's Hospital, Sydney, New South Wales 2010, Australia.
Yuen Y ChengAsbestos Diseases Research Institute, The University of Sydney, Sydney, New South Wales 2139, Australia.
Ruby C Y LinAsbestos Diseases Research Institute, The University of Sydney, Sydney, New South Wales 2139, Australia.
David M ThomasCancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
D Neil WatkinsCancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
Marcel E DingerKinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
Ann I McCormackHormones and Cancer Group, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
Mark J CowleyKinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
Garvan Institute of Medical Research · AUSt Vincent's Hospital Sydney · AUThe University of Sydney · AUPeter MacCallum Cancer Centre · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adrenocortical carcinoma is a rare malignancy with a poor prognosis and few treatment options. Molecular characterization of this cancer remains limited. We present a case of an adrenocortical carcinoma (ACC) in a 37-yr-old female, with dual lung metastases identified 1 yr following commencement of adjuvant mitotane therapy. As standard therapeutic regimens are often unsuccessful in ACC, we undertook a comprehensive genomic study into this case to identify treatment options and monitor disease progress. We performed targeted and whole-genome sequencing of germline, primary tumor, and both metastatic tumors from this patient and monitored recurrence over 2 years using liquid biopsy for ctDNA and steroid hormone measurements. Sequencing revealed the primary and metastatic tumors were hyperhaploid, with extensive loss of heterozygosity but few structural rearrangements. Loss-of-function mutations were identified in

Indexed as

Adrenal Cortex NeoplasmsAdrenocortical CarcinomaAdultHigh-Throughput Nucleotide SequencingHumansLiquid BiopsyLung NeoplasmsMicrosatellite InstabilityMutationPrognosisWhole Genome Sequencingadrenocortical carcinoma

Identifiers

PMID30936196
PMCPMC6549567
OpenAlexW2934369812

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.