Evidence map›Paper›PMID 30936182›Full record

ArticleDevelopment (Cambridge, England)2019

Rapid population-wide declines in stem cell number and activity during reproductive aging in

Zuzana Kocsisova, Kerry Kornfeld, Tim Schedl

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Apoptosis promotes fertility inbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Non-autonomy of age-related morphological changes in thebioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Single-tissue proteomics inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zuzana KocsisovaDepartment of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0002-8573-1376
Kerry KornfeldDepartment of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0002-6042-5241
Tim SchedlDepartment of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA ts@wustl.edu.ORCID 0000-0003-2148-2996

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Stem cell versus meiotic fate decision in C. elegansR01GM100756 · NIGMS · WASHINGTON UNIVERSITY · PI SCHEDL, TIM · 2012 to 2023
$4.2M
DISCOVER DETERMINANTS OF INDIVIDUAL LIFESPAN AND HEALTHR01AG057748 · NIA · WASHINGTON UNIVERSITY · PI KORNFELD, KERRY · 2019 to 2023
$2.1M
Identification of drugs that delay agingR56AG026561 · NIA · WASHINGTON UNIVERSITY · PI KORNFELD, KERRY · 2018 to 2018
$506k
NIA NIH HHS R01 AG057748NIA NIH HHS R56 AG026561NIGMS NIH HHS R01 GM100756NIH HHS P40 OD010440
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgingAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell CycleCell DifferentiationCell ProliferationFemaleGerm CellsOocytesReproductionSignal TransductionStem CellsCaenorhabditis elegans ProteinsCaenorhabditisCell cycleEndomitotic oocytesGermlineMeiotic developmentNotchReproductive agingStem cells

Identifiers

PMID30936182
PMCPMC6503983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.