Evidence map›Paper›PMID 30936178›Full record

ArticleDevelopment (Cambridge, England)2019

Defects in efferent duct multiciliogenesis underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient mice.

Berta Terré, Michael Lewis, Gabriel Gil-Gómez, Zhiyuan Han, Hao Lu, Mònica Aguilera, Neus Prats, Sudipto Roy, Haotian Zhao, Travis H Stracker

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Cilia Structure and Function in Human Disease.Current opinion in endocrine and metabolic research · 2024
    Article
  9. Formation and function of multiciliated cells.The Journal of cell biology · 2024
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Berta TerréInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona 08028, Spain.ORCID 0000-0002-0382-6129
Michael LewisInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona 08028, Spain.
Gabriel Gil-GómezApoptosis Signalling Group, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona 08003, Spain.ORCID 0000-0002-9790-7308
Zhiyuan HanDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, NY 11568, USA.
Hao LuInstitute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673, Singapore.
Mònica AguileraInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona 08028, Spain.ORCID 0000-0003-0763-7947
Neus PratsInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona 08028, Spain.
Sudipto RoyInstitute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673, Singapore.
Haotian ZhaoDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, NY 11568, USA.ORCID 0000-0003-2315-8452
Travis H StrackerInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona 08028, Spain travis.stracker@irbbarcelona.org.ORCID 0000-0002-8650-2081
Institute for Research in Biomedicine · ESNew York Institute of Technology · USHospital del Mar Research Institute · ESInstitute of Molecular and Cell Biology · SGNational University of Singapore · SG

Funding

The Impact of PD-1 Inhibition on Immune-Response to ChemoradiotherapyP20GM103548 · NIGMS · SANFORD RESEARCH/USD · PI MISKIMINS, W KEITH · 2012 to 2020
$20.8M
(PQ1) Molecular circuit of multi-ciliogenesis regulates choroid plexus differentiation and tumor developmentR01CA220551 · NCI · SANFORD RESEARCH/USD · PI ZHAO, HAOTIAN · 2017 to 2021
$1.7M
NCI NIH HHS R01 CA220551NIGMS NIH HHS P20 GM103548
6 · The paper itself

Abstract

GEMC1 and MCIDAS are geminin family proteins that transcriptionally activate E2F4/5-target genes during multiciliogenesis, including

Indexed as

AnimalsCell Cycle ProteinsCell LineDNA GlycosylasesEjaculatory DuctsEpididymisFluorescent Antibody TechniqueHumansImmunohistochemistryInfertility, MaleMaleMiceMice, Mutant StrainsNuclear ProteinsReal-Time Polymerase Chain ReactionTestisCell Cycle ProteinsDNA GlycosylasesGmnc protein, mouseMcidas protein, mouseNuclear ProteinsCCNOEfferent ductsFertilityGEMC1MCIDASMulticiliated cellsP73TestesTranscription

Identifiers

PMID30936178
PMCPMC6503982
OpenAlexW2934395624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.