Evidence map›Paper›PMID 30936141›Full record

ArticleDiabetes2019

A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease.

Jiantao Ma, Jana Nano, Jingzhong Ding, Yinan Zheng, Rachel Hennein, Chunyu Liu, Elizabeth K Speliotes, Tianxiao Huan, Ci Song, Michael M Mendelson and 27 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  16. Metabolic memory: mechanisms and diseases.Signal transduction and targeted therapy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 12 institutions in 6 countries.

Jiantao MaPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, and Framingham Heart Study, Framingham, MA.ORCID 0000-0001-7478-7203
Jana NanoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0003-4731-5491
Jingzhong DingDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC.
Yinan ZhengDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Rachel HenneinPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, and Framingham Heart Study, Framingham, MA.
Chunyu LiuPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, and Framingham Heart Study, Framingham, MA.
Elizabeth K SpeliotesUniversity of Michigan Medical School, Ann Arbor, MI.
Tianxiao HuanPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, and Framingham Heart Study, Framingham, MA.
Ci SongPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, and Framingham Heart Study, Framingham, MA.
Michael M MendelsonPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, and Framingham Heart Study, Framingham, MA.
Roby JoehanesPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, and Framingham Heart Study, Framingham, MA.
Michelle T LongSection of Gastroenterology, Department of Medicine, Boston University School of Medicine, Boston, MA.
Liming LiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
Lindsay M ReynoldsDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC.
Mohsen GhanbariDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Taulant MukaDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Joyce B J van MeursDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Louise J M AlferinkDepartment of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Scott RatliffDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
Lawrence BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.
Hongyan NingDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Lisa B VanWagnerDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Donald M Lloyd-JonesDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
John Jeffrey CarrDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN.
Philip GreenlandDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Alice H LichtensteinCardiovascular Nutrition Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA.
Frank B HuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
Yongmei LiuDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC.
Lifang HouDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Sarwa Darwish MuradDepartment of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Daniel LevyPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, and Framingham Heart Study, Framingham, MA levyd@nhlbi.nih.gov.ORCID 0000-0003-1843-8724
Erasmus MC · NLUniversity of Michigan · USNorthwestern University · USNational Institutes of Health · USWake Forest University · USBoston University · USHarvard University · USTufts University · USBoston Children's Hospital · USMashhad University of Medical Sciences · IRUppsala University · SEVanderbilt University Medical Center · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
The Family Blood Pressure Program (GENOA Network)U01HL054481 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A · 2000 to 2007
$6.7M
Longitudinal Changes in Pericardial Adiposity and Subclinical AtherosclerosisR01HL098445 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CARR, JOHN JEFFREY · 2010 to 2013
$4.6M
Epigenome-Wide Association Study of DNA Methylation and AtherosclerosisR01HL101250 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LIU, YONGMEI · 2009 to 2013
$3.6M
Human population based genetic studies to elucidate the biology of NAFLDR01DK107904 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPELIOTES, ELIZABETH K · 2016 to 2020
$3.4M
Identification and functional impact of NAFLD associated genetic variantsR01DK106621 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPELIOTES, ELIZABETH K · 2015 to 2019
$3.3M
GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPSU01HL054457 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARDIA, SHARON L · 2000 to 2004
$2.8M
NHLBI FAMILY BLOOD PRESSURE PROGRAM (GENOA)U01HL054464 · NHLBI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI TURNER, STEPHEN T · 2000 to 2004
$2.6M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS K22 HL135075NHLBI NIH HHS K23 HL136891NHLBI NIH HHS K99 HL136875NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL085571NHLBI NIH HHS R01 HL098445NHLBI NIH HHS R01 HL101250NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL133221NHLBI NIH HHS RC1 HL100185NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL054464NHLBI NIH HHS U01 HL054481NHLBI NIH HHS U10 HL054457NHLBI NIH HHS U10 HL054464NHLBI NIH HHS U10 HL054481NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK106621NIDDK NIH HHS R01 DK107904
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes (T2D). We aimed to identify the peripheral blood DNA methylation signature of hepatic fat. We conducted epigenome-wide association studies of hepatic fat in 3,400 European ancestry (EA) participants and in 401 Hispanic ancestry and 724 African ancestry participants from four population-based cohort studies. Hepatic fat was measured using computed tomography or ultrasound imaging and DNA methylation was assessed at >400,000 cytosine-guanine dinucleotides (CpGs) in whole blood or CD14+ monocytes using a commercial array. We identified 22 CpGs associated with hepatic fat in EA participants at a false discovery rate <0.05 (corresponding

Indexed as

BiomarkersDiabetes Mellitus, Type 2DNA MethylationFatsFemaleHumansLipopolysaccharide ReceptorsLiverMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseRisk FactorsBiomarkersFatsLipopolysaccharide Receptors

Identifiers

PMID30936141
PMCPMC6477898
OpenAlexW2916486264

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.