Evidence map›Paper›PMID 30935842›Full record

Observational studyJournal of cardiovascular computed tomography

Coronary artery calcium scoring in low risk patients with family history of coronary heart disease: Validation of the SCCT guideline approach in the coronary artery calcium consortium.

Ramzi Dudum, Omar Dzaye, Mohammadhassan Mirbolouk, Zeina A Dardari, Olusola A Orimoloye, Matthew J Budoff, Daniel S Berman, Alan Rozanski, Michael D Miedema, Khurram Nasir and 5 more

Open access · greenAbstract readMulticenter StudyObservational StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cardiovascular computed tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

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  19. Subclinical cardiovascular disease and utility of coronary artery calcium score.International journal of cardiology. Heart & vasculature · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 2 countries.

Ramzi DudumDepartment of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA; Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA.
Omar DzayeJohns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Radiology and Neuroradiology, Charité, Berlin, Germany.
Mohammadhassan MirboloukJohns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA.
Zeina A DardariJohns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA.
Olusola A OrimoloyeJohns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA.
Matthew J BudoffDepartment of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.
Daniel S BermanDepartment of Nuclear Cardiology/Cardiac Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Alan RozanskiDepartment of Medicine, St. Luke's Roosevelt Hospital Center, New York, NY, USA.
Michael D MiedemaMinneapolis Heart Institute and Minneapolis Heart Institute Foundation, Minneapolis, MN, USA.
Khurram NasirDepartment of Medicine, Yale School of Medicine, New Haven, CT, USA; Center for Outcomes Research & Evaluation, Yale School of Medicine, New Haven, CT, USA.
John A RumbergerDepartment of Cardiovascular Imaging, Princeton Longevity Center, Princeton, NJ, USA.
Leslee ShawDepartment of Radiology and Medicine, Weill Cornell Medical College, New York, NY, USA.
Seamus P WheltonDepartment of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA; Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA.
Garth GrahamAetna Foundation, Hartford, CT, USA.
Michael J BlahaDepartment of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA; Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA. Electronic address: mblaha1@jhmi.edu.
Johns Hopkins University · USAetna (United States) · USCedars-Sinai Medical Center · USCornell University · USMinneapolis Heart Institute Foundation · USPrinceton University · USSt. Luke's-Roosevelt Hospital Center · USUCLA Medical Center · USYale New Haven Hospital · US

Funding

NHLBI NIH HHS L30 HL110027
6 · The paper itself

Abstract

backgroundThe Society of Cardiovascular Computed Tomography (SCCT) recommends consideration of coronary artery calcium (CAC) scoring among individuals with a family history (FH) of coronary heart disease (CHD) and atherosclerotic cardiovascular disease (ASCVD) risk <5%. No dedicated study has examined the prognostic significance of CAC scoring among this population.

methodsThe CAC Consortium is a multi-center observational cohort study from four clinical centers linked to long-term follow-up for cause-specific mortality. All CAC scans were physician referred and performed in patients without a history of CHD. Our analysis includes 14,169 patients with ASCVD scores <5% and self-reported FH of CHD.

resultsThis cohort had a mean age of 48.1 (SD 7.4), was 91.3% white, 47.4% female, had an average ASCVD score of 2.3% (SD 1.3), and 59.4% had a CAC = 0. The event rate for all-cause mortality was 1.2 per 1000 person-years, 0.3 per 1000 person-years for CVD-specific mortality, and 0.2 per 1000 person-years for CHD-specific mortality. In multivariable Cox proportional hazard models, those with CAC>100 had a 2.2 (95% CI 1.5-3.3) higher risk of all-cause mortality, 4.3 (95% CI 1.9-9.5) times higher risk of CVD-specific mortality, and a 10.4 (95% CI 3.2-33.7) times higher risk of CHD-specific mortality compared to individuals with CAC = 0. The NNS to detect CAC >100 in this sample was 9.

conclusionIn otherwise low risk patients with FH of CHD, CAC>100 were associated with increased risk of all-cause and CHD mortality with event rates in a range that may benefit with preventive pharmacotherapy. These data strongly support new SCCT recommendations regarding testing of patients with a family history of CHD.

Indexed as

AdultComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseDatabases, FactualFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedPedigreePhenotypePractice Guidelines as TopicPredictive Value of TestsPrognosisReproducibility of ResultsComputed tomographyCoronary artery calciumCoronary heart diseaseFamily history

Identifiers

PMID30935842
PMCPMC6663654
OpenAlexW2930787761

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.