ArticleBMC plant biology2019
High accumulation of γ-linolenic acid and Stearidonic acid in transgenic Perilla (Perilla frutescens var. frutescens) seeds.
Article in BMC plant biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
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- The role of total polysaccharides fromFrontiers in pharmacology · 2025Article
- Biomass Potential of Alkaline-PretreatedJournal of applied glycoscience · 2025Article
- Perilla Seed Oil: A Review of Health Effects, Encapsulation Strategies and Applications in Food.Foods (Basel, Switzerland) · 2024Review
- Article
- Crucial amino acids identified in Δ12 fatty acid desaturases related to linoleic acid production inFrontiers in plant science · 2024Article
- Integrative physiological, transcriptomic, and metabolomic analysis ofFrontiers in plant science · 2024Article
- Promising Sources of Plant-Derived Polyunsaturated Fatty Acids: A Narrative Review.International journal of environmental research and public health · 2023Review
- Article
- Integrative iTRAQ-based proteomic and transcriptomic analysis reveals the accumulation patterns of key metabolites associated with oil quality during seed ripening of Camellia oleifera.Horticulture research · 2021Article
- Assessment of genetic diversity and population structure among a collection of Korean Perilla germplasms based on SSR markers.Genes & genomics · 2020Article
- Metabolite Profiling and Chemometric Study for the Discrimination Analyses of Geographic Origin of Perilla (Foods (Basel, Switzerland) · 2020Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPolyunsaturated fatty acids such as linoleic acid (LA) and α-linolenic acid (ALA) are abundant in vegetable oils and are important for human health. In the body, LA and ALA are respectively converted to the omega-6 fatty acid γ-linolenic acid (GLA) and the omega-3 fatty acid stearidonic acid (SDA) by Δ6 desaturase (D6DES). Currently, dietary GLA and SDA are mainly obtained from marine organisms, but given their benefits to human health, many studies have aimed to enhance their accumulation in transgenic crops. Perilla frutescens (perilla) accumulates more ALA in its seed oil compared to other oilseed crops, making it a good candidate for the production of fatty acids via the fatty acid desaturase D6DES.
resultsIn this study, we cloned the D6DES gene from Phytophthora citrophthora and confirmed its function in budding yeast. We then transformed the functional D6DES gene under the control of the seed-specific vicilin promoter into the perilla cultivar Yeobsil. The resulting transgenic perilla seeds accumulated significant levels of GLA and SDA, as well as putative C18:2Δ
conclusionsThus, PcD6DES perilla plants may represent a feasible alternative to traditional marine sources for the production of omega-3 oil capsules and to evening primrose seed oil for GLA as health food. In addition, these plants can be used to create other transgenic lines harboring additional genes to produce other desirable fish-oil like oils.
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