Evidence map›Paper›PMID 30935163›Full record

ArticleMaterials (Basel, Switzerland)2019

Fluid Cartilage as New Autologous Biomaterial in the Treatment of Minor Nose Defects: Clinical and Microscopic Difference Amongst Diced, Crushed, and Fluid Cartilage.

Angelo Trivisonno, Steven R Cohen, Guy Magalon, Jèrèmy Magalon, Aris Sterodimas, Michele Pascali, Valerio Cervelli, Gabriele Toietta, Alfredo Colaprietra, Filippo Calcagni and 3 more

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Dorsal Augmentation Rhinoplasty by Cartilage Allograft.Journal of cosmetic dermatology · 2025
    Article
  2. Article
  3. Review
  4. Sliced vs crushed cartilage for camouflage: long-term graft survival and histological outcomes.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Angelo TrivisonnoDepartment of Surgical Science University of Rome "La Sapienza", Rome 00161, Italy. angelo.trivisonno@uniroma1.it.
Steven R CohenFACES+ Plastic Surgery, Skin and Laser Center, La Jolla CA 92121, USA and Division of Plastic Surgery, University of California San Diego, San Diego, CA 92121, USA. scohen@facesplus.com.
Guy MagalonCell Therapy Laboratory, CBT-1409, INSERM, Assistance Publique Hôpitaux de Marseille, Marseille 13005, France. g.magalon@gmail.com.
Jèrèmy MagalonPlastic Surgery Department, Assistance Publique Hôpitaux de Marseille (APHM), Aix Marseille University, Marseille 13005, France. Jeremy.MAGALON@ap-hm.fr.
Aris SterodimasDepartment of Plastic Surgery, IASO General Hospital, Athens 15562, Greece. aris@sterodimas.com.
Michele PascaliDepartment of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome 00133, Italy. michelepascali.plasticsurgeon@gmail.com.
Valerio CervelliDepartment of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome 00133, Italy. valeriocervelli@virgilio.it.
Gabriele ToiettaDepartment of Research, Advanced Diagnostic, and Technological Innovation, Regina Elena National Cancer Institute, Rome 00144, Italy. gabriele.toietta@ifo.gov.it.
Alfredo ColaprietraDepartment of Plastic Surgery, Campus Bio-Medico University of Rome, Rome 00128, Italy. colapietra.alfredo@gmail.com.
Filippo CalcagniDepartment of Plastic Surgery Catholic University of the Sacred Heart, Rome 00168, Italy. filippo.calcagni@gmail.com.
Augusto OrlandiDepartment of Biomedicine and Prevention, Tor Vergata University of Rome, Rome 00133, Italy. scioli@med.uniroma2.it.
Maria Giovanni ScioliDepartment of Biomedicine and Prevention, Tor Vergata University of Rome, Rome 00133, Italy. scioli@med.uniroma2.it.
Pietro GentileDepartment of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome 00133, Italy. pietrogentile2004@libero.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developing cartilage constructs with injectability, appropriate matrix composition, and persistent cartilaginous phenotype remains an enduring challenge in cartilage repair. Fourteen patients with minor contour deformity were treated with fluid cartilage filler gently injected as autologous fluid graft in deep planes of defect of the nose that were close to the bone or the cartilage. A computerized tomographic scan control was performed after 12 months. Pearson's Chi-square test was used to investigate differences in cartilage density between native and newly formed cartilages. The endpoints were the possibility of using fluid cartilage as filler with aesthetic and functional improvement and versatility. Patients were followed up for two years. The constructs of fluid cartilage graft that were injected in the deep plane resulted in a persistent cartilage tissue with appropriate morphology, adequate central nutritional perfusion without central necrosis or ossification, and further augmented nasal dorsum without obvious contraction and deformation. This report demonstrated that fluid cartilage grafts are useful for cartilage regeneration in patients with outcomes of rhinoplasty, internal nasal valve collapse, and minor congenital nose aesthetics deformity.

Indexed as

crushing cartilagediced cartilagefluid cartilageminor nose defectsrhinoplasty

Identifiers

PMID30935163
PMCPMC6479609

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.