Evidence map›Paper›PMID 30935133›Full record

ArticleNutrients2019

Evolution of Anemia Types During Antiretroviral Therapy-Implications for Treatment Outcomes and Quality of Life Among HIV-Infected Adults.

Amara E Ezeamama, Alla Sikorskii, Ramanpreet K Bajwa, Robert Tuke, Rachel B Kyeyune, Jenifer I Fenton, David Guwatudde, Wafaie W Fawzi

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Anemia, Iron Status, and HIV: A Systematic Review of the Evidence.Advances in nutrition (Bethesda, Md.) · 2020
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Approaches to Address the Anemia Challenge.The Journal of nutrition · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Amara E EzeamamaDepartment of Psychiatry, College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA. amara.ezeamama@hc.msu.edu.
Alla SikorskiiDepartment of Psychiatry, College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA. Alla.Sikorskii@hc.msu.edu.
Ramanpreet K BajwaCollege of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA. Bajwaram@msu.edu.
Robert TukeDepartment of Psychiatry, College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA. tukerobe@msu.edu.
Rachel B KyeyuneNational Drug Authority, 23096 Kampala, Uganda. rbkyeyune@gmail.com.
Jenifer I FentonDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA. imigjeni@msu.edu.
David GuwatuddeSchool of Public Health, Makerere University College of Health Sciences, P.O. Box 7062 Kampala, Uganda. dguwatudde@musph.ac.ug.
Wafaie W FawziDepartments of Global Health and Population, Nutrition and Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA. mina@hsph.harvard.edu.
Michigan State University · USHarvard Global Health Institute · USMakerere University · UG

Funding

Multi-vitamins, HAART and HIV/AIDS in UgandaR01HD060333 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI FAWZI, WAFAIE W · 2008 to 2012
$1.6M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD060333International AIDS Society 327-EZE, CIPHERMichigan State University Alliance for African Partnership RN100284
6 · The paper itself

Abstract

This study examined whether the type of anemia in persons living with HIV/AIDS (PLWHA) changed from the beginning of highly antiretroviral therapy (HAART) and had implications for treatment outcomes and quality of life (QOL). If present, the anemia-type was defined as microcytic, macrocytic or anemia of chronic disease (ACD) at study months 0, 6, 12, and 18. Multinomial logistic regression quantified sociodemographic and HIV-treatment factors associated with incident microcytic anemia or ACD over 18 months. Repeated measures linear regression models estimated the anemia-type associated change in the CD4 cell-count, QOL, body mass index (BMI) and frailty over 18 months. Cox proportional hazard models estimated associations between anemia-type and time to (a) gain at least 100 CD4 cells/L and (b) hospitalization/death. Analyses were implemented in Statistical Analysis Software (v.9.4) from which odds ratios (ORs) mean differences (β) and corresponding 95% confidence intervals (CI) were estimated. At enrollment, ACD, macrocytic and microcytic anemia was present in 36.8% (

Indexed as

Antiretroviral Therapy, Highly ActiveQuality of LifeAdolescentAdultAnemiaAnti-HIV AgentsCD4 Lymphocyte CountFemaleHIV InfectionsHumansMaleViral LoadYoung AdultAnti-HIV Agentsanemiaanemia of chronic diseaseanemia typeantiretroviral therapyclinical outcomesferritinHIVmacrocytosismicrocytosisquality of life

Identifiers

PMID30935133
PMCPMC6521252
OpenAlexW2930019989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.