Evidence map›Paper›PMID 30935124›Full record

ArticleMedicina (Kaunas, Lithuania)2019

5-Arylidene(chromenyl-methylene)-thiazolidinediones: Potential New Agents against Mutant Oncoproteins K-Ras, N-Ras and B-Raf in Colorectal Cancer and Melanoma.

Cristina Nastasă, Radu Tamaian, Ovidiu Oniga, Brîndușa Tiperciuc

Open access · goldAbstract read
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Cristina NastasăDepartment of Pharmaceutical chemistry, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. cmoldovan@umfcluj.ro.ORCID 0000-0002-5803-6108
Radu TamaianNational Research and Development Institute for Cryogenics and Isotopic Technologies, ICSI Analytics, 4th Uzinei Street, RO-240050 Râmnicu Vâlcea, Romania. radu.tamaian@gmail.com.ORCID 0000-0001-6380-1460
Ovidiu OnigaDepartment of Pharmaceutical chemistry, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. onigao65@yahoo.com.
Brîndușa TiperciucDepartment of Pharmaceutical chemistry, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania. brandu32@yahoo.com.ORCID 0000-0002-1333-5649
Iuliu Hațieganu University of Medicine and Pharmacy · RONational Institute for Research and Development of Isotopic and Molecular Technologies · RO

Funding

"Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca internal research grant No. 4944/7/08.03.2016 (Cristina Nastasă)The Executive Agency for Higher Education Research Development and Innovation Funding - UEFISCDI, Romania Contract 210/2014 - Project PN-II-PT-PCCA-2013-4-2075 (Radu Tamaian)
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntineoplastic AgentsCell Line, TumorCell SurvivalColorectal NeoplasmsDrug DiscoveryGTP PhosphohydrolasesGuanosine DiphosphateHumansMelanomaMelanoma, ExperimentalMiceMolecular Docking SimulationMutationOncogene Protein p21(ras)Protein BindingAntineoplastic AgentsGTP PhosphohydrolasesGuanosine DiphosphateOncogene Protein p21(ras)Proto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)thiazolidine-2,4-dioneThiazolidinedionesADME-ToxB-RafcytotoxicityK-Rasmolecular dockingN-Rasthiazolidine-2,4-dione

Identifiers

PMID30935124
PMCPMC6524019
OpenAlexW2935502512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.